Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, B-1200 Brussels, Belgium.
Nutrients. 2018 Apr 25;10(5):532. doi: 10.3390/nu10050532.
Postprandial hyperlipidemia is an important risk factor for cardiovascular diseases in the context of obesity. Inulin is a non-digestible carbohydrate, known for its beneficial properties in metabolic disorders. We investigated the impact of inulin on postprandial hypertriglyceridemia and on lipid metabolism in a mouse model of diet-induced obesity. Mice received a control or a western diet for 4 weeks and were further supplemented or not with inulin for 2 weeks (0.2 g/day per mouse). We performed a lipid tolerance test, measured mRNA expression of genes involved in postprandial lipid metabolism, assessed post-heparin plasma and muscle lipoprotein lipase activity and measured lipid accumulation in the enterocytes and fecal lipid excretion. Inulin supplementation in western diet-fed mice decreases postprandial serum triglycerides concentration, decreases the mRNA expression levels of (fatty acid receptor involved in lipid uptake and sensing) and apolipoprotein C3 (, inhibitor of lipoprotein lipase) in the jejunum and increases fecal lipid excretion. In conclusion, inulin improves postprandial hypertriglyceridemia by targeting intestinal lipid metabolism. This work confirms the interest of using inulin supplementation in the management of dyslipidemia linked to obesity and cardiometabolic risk.
餐后高脂血症是肥胖背景下心血管疾病的一个重要危险因素。菊粉是一种不可消化的碳水化合物，因其在代谢紊乱方面的有益特性而闻名。我们研究了菊粉对饮食诱导肥胖小鼠模型餐后高甘油三酯血症和脂代谢的影响。小鼠接受对照或西式饮食 4 周，并用或不用菊粉进一步补充 2 周（每天每只小鼠 0.2 克）。我们进行了脂质耐量试验，测量了参与餐后脂质代谢的基因的 mRNA 表达水平，评估了肝素后血浆和肌肉脂蛋白脂肪酶活性，并测量了肠细胞中的脂质积累和粪便脂质排泄。在西方饮食喂养的小鼠中补充菊粉可降低餐后血清甘油三酯浓度，降低空肠中脂肪酸受体（参与脂质摄取和感应的脂肪酸受体）和载脂蛋白 C3（脂蛋白脂肪酶抑制剂）的 mRNA 表达水平，并增加粪便脂质排泄。总之，菊粉通过靶向肠道脂质代谢改善了餐后高甘油三酯血症。这项工作证实了在肥胖和心脏代谢风险相关的血脂异常管理中使用菊粉补充剂的益处。
