金纳米棒的亲水性和疏水性功能化对金黄色葡萄球菌和痤疮丙酸杆菌的光热消融效应。
Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes.
机构信息
Department of Pharmaceutics & Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, 11942, Jordan.
Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, Jordan.
出版信息
Sci Rep. 2018 May 2;8(1):6881. doi: 10.1038/s41598-018-24837-7.
The potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by measuring the percentage reduction of bacterial viable count upon GNR excitation with a near infra-red (NIR) laser beam. Our results suggest that functionalized GNR had a minimal bactericidal activity against S. aureus and P. acnes (≤85%, i.e. ≤1 log cycle reduction of bacterial viable count). However, the local heat generated upon exciting the functionalized GNR with NIR laser beam has a significant photothermal ablation effect (≥99.99%, i.e. ≥4 log cycles reduction of bacterial viable count). Such photothermolysis effect could potentiate the antibacterial activity of GNR, which may call for minimum concentration and side effects of these nanotherapeutics.
通过测量金纳米棒（GNR）在近红外（NIR）激光激发下的细菌存活数减少百分比，评估了亲水功能化聚乙二醇（PEG）-GNR 和疏水性功能化聚苯乙烯（PS）-GNR 对金黄色葡萄球菌（S. aureus）和痤疮丙酸杆菌（P. acnes）菌株的潜在光热杀菌活性。我们的结果表明，功能化 GNR 对 S. aureus 和 P. acnes 的杀菌活性最小（≤85%，即细菌存活数减少≤1 对数循环）。然而，用 NIR 激光激发功能化 GNR 产生的局部热量具有显著的光热消融效应（≥99.99%，即细菌存活数减少≥4 对数循环）。这种光热分解效应可以增强 GNR 的抗菌活性，这可能需要这些纳米治疗剂的最低浓度和副作用。
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