Department of Pharmaceutics & Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, 11942, Jordan.
Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, Jordan.
Sci Rep. 2018 May 2;8(1):6881. doi: 10.1038/s41598-018-24837-7.
The potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by measuring the percentage reduction of bacterial viable count upon GNR excitation with a near infra-red (NIR) laser beam. Our results suggest that functionalized GNR had a minimal bactericidal activity against S. aureus and P. acnes (≤85%, i.e. ≤1 log cycle reduction of bacterial viable count). However, the local heat generated upon exciting the functionalized GNR with NIR laser beam has a significant photothermal ablation effect (≥99.99%, i.e. ≥4 log cycles reduction of bacterial viable count). Such photothermolysis effect could potentiate the antibacterial activity of GNR, which may call for minimum concentration and side effects of these nanotherapeutics.
通过测量金纳米棒（GNR）在近红外（NIR）激光激发下的细菌存活数减少百分比，评估了亲水功能化聚乙二醇（PEG）-GNR 和疏水性功能化聚苯乙烯（PS）-GNR 对金黄色葡萄球菌（S. aureus）和痤疮丙酸杆菌（P. acnes）菌株的潜在光热杀菌活性。我们的结果表明，功能化 GNR 对 S. aureus 和 P. acnes 的杀菌活性最小（≤85%，即细菌存活数减少≤1 对数循环）。然而，用 NIR 激光激发功能化 GNR 产生的局部热量具有显著的光热消融效应（≥99.99%，即细菌存活数减少≥4 对数循环）。这种光热分解效应可以增强 GNR 的抗菌活性，这可能需要这些纳米治疗剂的最低浓度和副作用。
