Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.
Department of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, Via Álvaro del Portillo 21, 00128 Rome, Italy.
Oxid Med Cell Longev. 2018 Mar 21;2018:7924021. doi: 10.1155/2018/7924021. eCollection 2018.
Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10-15% prevalence in the general female population, rising up to 30-45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis. In particular, it is marked by an inflammatory process associated with the overproduction of an array of inflammatory mediators such as prostaglandins, metalloproteinases, cytokines, and chemokines. In addition, the growth and adhesion of endometrial cells in the peritoneal cavity due to reactive oxygen species (ROS) and free radicals lead to disease onset, its ensuing symptoms-among which pain and infertility. The aim of our review is to evaluate the role of oxidative stress and ROS in the pathogenesis of endometriosis and the efficacy of antioxidant therapy in the treatment and mitigation of its symptoms.
子宫内膜异位症是一种以子宫内膜组织出现在子宫腔外为特征的疾病，导致慢性炎症反应。它是最常见的妇科疾病之一，在普通女性人群中的患病率为 10-15%，在不孕患者中上升至 30-45%。尽管它于 1860 年首次被描述，但它的病因和发病机制仍不清楚。现在人们认为炎症在子宫内膜异位症的发展和进展中起着核心作用。特别是，它的特征是与前列腺素、金属蛋白酶、细胞因子和趋化因子等一系列炎症介质过度产生相关的炎症过程。此外，由于活性氧（ROS）和自由基，子宫内膜细胞在腹腔内的生长和黏附导致疾病发作，进而出现疼痛和不孕等症状。我们的综述旨在评估氧化应激和 ROS 在子宫内膜异位症发病机制中的作用，以及抗氧化治疗在治疗和缓解其症状方面的疗效。
