Blowman K, Magalhães M, Lemos M F L, Cabral C, Pires I M
School of Life Sciences, University of Hull, Hull HU6 7RX, UK.
REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
Evid Based Complement Alternat Med. 2018 Mar 25;2018:3149362. doi: 10.1155/2018/3149362. eCollection 2018.
Essential oils are secondary metabolites with a key-role in plants protection, consisting primarily of terpenes with a volatile nature and a diverse array of chemical structures. Essential oils exhibit a wide range of bioactivities, especially antimicrobial activity, and have long been utilized for treating various human ailments and diseases. Cancer cell prevention and cytotoxicity are exhibited through a wide range of mechanisms of action, with more recent research focusing on synergistic and antagonistic activity between specific essential oils major and minor components. Essential oils have been shown to possess cancer cell targeting activity and are able to increase the efficacy of commonly used chemotherapy drugs including paclitaxel and docetaxel, having also shown proimmune functions when administered to the cancer patient. The present review represents a state-of-the-art review of the research behind the application of EOs as anticancer agents both and . Cancer cell target specificity and the use of EOs in combination with conventional chemotherapeutic strategies are also explored.
精油是植物保护中的关键次生代谢产物,主要由具有挥发性且化学结构多样的萜类化合物组成。精油具有广泛的生物活性,尤其是抗菌活性,长期以来一直用于治疗各种人类疾病。癌细胞预防和细胞毒性通过多种作用机制表现出来,最近的研究集中在特定精油主要成分和次要成分之间的协同和拮抗活性上。精油已被证明具有癌细胞靶向活性,并且能够提高常用化疗药物(包括紫杉醇和多西他赛)的疗效,在给癌症患者使用时也显示出免疫促进功能。本综述代表了对精油作为抗癌剂应用背后研究的最新综述。还探讨了癌细胞靶向特异性以及精油与传统化疗策略联合使用的情况。