Wu Yuanzi, Jiang Ye, Zheng Xiaoshan, Jia Shasha, Zhu Zhi, Ren Bin, Ma Hongwei
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350002, People's Republic of China.
State Key Laboratory of Physical Chemistry of Solid Surfaces, the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, and Collaborative Innovation Center of Chemistry of Energy Materials, Xiamen University, Xiamen 361005, People's Republic of China.
R Soc Open Sci. 2018 Apr 4;5(4):172034. doi: 10.1098/rsos.172034. eCollection 2018 Apr.
We describe a facile and low-cost approach for a flexibly integrated surface-enhanced Raman scattering (SERS) substrate in microfluidic chips. Briefly, a SERS substrate was fabricated by the electrostatic assembling of gold nanoparticles, and shaped into designed patterns by subsequent lift-up soft lithography. The SERS micro-pattern could be further integrated within microfluidic channels conveniently. The resulting microfluidic SERS chip allowed ultrasensitive SERS monitoring from the transparent glass window. With its advantages in simplicity, functionality and cost-effectiveness, this method could be readily expanded into optical microfluidic fabrication for biochemical applications.
我们描述了一种用于在微流控芯片中灵活集成表面增强拉曼散射（SERS）基底的简便且低成本的方法。简而言之，通过金纳米颗粒的静电组装制备了SERS基底，并通过随后的提拉软光刻将其成型为设计图案。SERS微图案可以方便地进一步集成到微流控通道内。所得的微流控SERS芯片允许从透明玻璃窗进行超灵敏的SERS监测。由于其在简单性、功能性和成本效益方面的优势，该方法可以很容易地扩展到用于生化应用的光学微流控制造中。
