Lyall Laura M, Wyse Cathy A, Graham Nicholas, Ferguson Amy, Lyall Donald M, Cullen Breda, Celis Morales Carlos A, Biello Stephany M, Mackay Daniel, Ward Joey, Strawbridge Rona J, Gill Jason M R, Bailey Mark E S, Pell Jill P, Smith Daniel J
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; Department of Molecular and Cellular Therapeutics, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
Lancet Psychiatry. 2018 Jun;5(6):507-514. doi: 10.1016/S2215-0366(18)30139-1. Epub 2018 May 15.
Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder.
UK residents aged 37-73 years were recruited into the UK Biobank general population cohort from 2006 to 2010. We used data from a subset of participants whose activity levels were recorded by wearing a wrist-worn accelerometer for 7 days. From these data, we derived a circadian relative amplitude variable, which is a measure of the extent to which circadian rhythmicity of rest-activity cycles is disrupted. In the same sample, we examined cross-sectional associations between low relative amplitude and mood disorder, wellbeing, and cognitive variables using a series of regression models. Our final model adjusted for age and season at the time that accelerometry started, sex, ethnic origin, Townsend deprivation score, smoking status, alcohol intake, educational attainment, overall mean acceleration recorded by accelerometry, body-mass index, and a binary measure of childhood trauma.
We included 91 105 participants with accelerometery data collected between 2013 and 2015 in our analyses. A one-quintile reduction in relative amplitude was associated with increased risk of lifetime major depressive disorder (odds ratio [OR] 1·06, 95% CI 1·04-1·08) and lifetime bipolar disorder (1·11, 1·03-1·20), as well as with greater mood instability (1·02, 1·01-1·04), higher neuroticism scores (incident rate ratio 1·01, 1·01-1·02), more subjective loneliness (OR 1·09, 1·07-1·11), lower happiness (0·91, 0·90-0·93), lower health satisfaction (0·90, 0·89-0·91), and slower reaction times (linear regression coefficient 1·75, 1·05-2·45). These associations were independent of demographic, lifestyle, education, and overall activity confounders.
Circadian disruption is reliably associated with various adverse mental health and wellbeing outcomes, including major depressive disorder and bipolar disorder. Lower relative amplitude might be linked to increased susceptibility to mood disorders.
Lister Institute of Preventive Medicine.
睡眠和昼夜节律紊乱是情绪障碍的核心特征，可能与这类疾病易感性增加有关。该领域以往的研究使用了关于活动和睡眠模式的主观报告，但英国生物银行参与者基于加速度计的数据，使我们能够推导和分析新的、客观确定的昼夜节律参数。我们研究了客观评估的昼夜节律与心理健康和幸福感表型（包括情绪障碍的终生病史）之间的关联。
2006年至2010年，37 - 73岁的英国居民被纳入英国生物银行普通人群队列。我们使用了一部分参与者的数据，这些参与者通过佩戴腕部加速度计记录了7天的活动水平。从这些数据中，我们推导出一个昼夜相对振幅变量，它衡量了休息 - 活动周期的昼夜节律被打乱的程度。在同一样本中，我们使用一系列回归模型研究了低相对振幅与情绪障碍、幸福感和认知变量之间的横断面关联。我们的最终模型对加速度计开始记录时的年龄和季节、性别、种族、汤森贫困得分、吸烟状况、酒精摄入量、教育程度、加速度计记录的总体平均加速度、体重指数以及童年创伤的二元测量进行了调整。
我们的分析纳入了2013年至2015年期间收集加速度计数据的91105名参与者。相对振幅每降低五分之一，与终生重度抑郁症风险增加（优势比[OR]1.06，95%置信区间1.04 - 1.08）、终生双相情感障碍风险增加（1.11，1.03 - 1.20）相关，还与情绪更不稳定（1.02，1.01 - 1.04）、神经质得分更高（发病率比1.01，1.01 - 1.02）、更多主观孤独感（OR 1.09，1.07 - 1.11）、更低的幸福感（0.91，0.90 - 0.93）、更低的健康满意度（0.90，0.89 - 0.91）以及反应时间更慢（线性回归系数1.75，1.05 - 2.45）相关。这些关联独立于人口统计学、生活方式、教育和总体活动混杂因素。
昼夜节律紊乱与各种不良心理健康和幸福感结果可靠相关，包括重度抑郁症和双相情感障碍。较低的相对振幅可能与情绪障碍易感性增加有关。
李斯特预防医学研究所。
