Wilson Blake S
Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
World J Otorhinolaryngol Head Neck Surg. 2018 Jan 3;3(4):200-210. doi: 10.1016/j.wjorl.2017.12.005. eCollection 2017 Dec.
BACKGROUND: The cochlear implant has become the standard of care for severe or worse losses in hearing and indeed has produced the first substantial restoration of a lost or absent human sense using a medical intervention. However, the devices are not perfect and many efforts to narrow the remaining gaps between prosthetic and normal hearing are underway. OBJECTIVE: To assess the present status of cochlear implants and to describe possibilities for improving them. RESULTS: The present-day devices work well in quiet conditions for the great majority of users. However, not all users have high levels of speech reception in quiet and nearly all users struggle with speech reception in typically noisy acoustic environments. In addition, perception of sounds more complex than speech, such as most music, is generally poor unless residual hearing at low frequencies can be stimulated acoustically in conjunction with the electrical stimuli provided by the implant. Possibilities for improving the present devices include increasing the spatial specificity of neural excitation by reducing masking effects or with new stimulus modes; prudent pruning of interfering or otherwise detrimental electrodes from the stimulation map; a further relaxation in the criteria for implant candidacy, based on recent evidence from persons with high levels of residual hearing and to allow many more people to benefit from cochlear implants; and "top down" or "brain centric" approaches to implant designs and applications. CONCLUSIONS: Progress in the development of the cochlear implant and related treatments has been remarkable but room remains for improvements. The future looks bright as there are multiple promising possibilities for improvements and many talented teams are pursuing them.
背景:人工耳蜗已成为重度或更严重听力损失的标准治疗手段,并且确实首次通过医学干预实质性地恢复了丧失或缺失的人类感官。然而,这些设备并不完美,目前正在进行许多努力以缩小人工耳蜗与正常听力之间的差距。 目的:评估人工耳蜗的现状并描述改进它们的可能性。 结果:当今的设备在安静环境中对大多数使用者效果良好。然而,并非所有使用者在安静环境下都有高水平的言语接受能力,并且几乎所有使用者在典型的嘈杂声学环境中都难以进行言语接受。此外,对于比言语更复杂的声音感知,例如大多数音乐,通常很差,除非低频残余听力能够与植入物提供的电刺激一起通过声学方式被刺激。改进现有设备的可能性包括通过减少掩蔽效应或采用新的刺激模式来提高神经兴奋的空间特异性;从刺激图谱中谨慎去除干扰性或其他有害电极;根据近期对具有高水平残余听力者的研究证据,进一步放宽植入候选标准,以使更多人能够受益于人工耳蜗;以及采用“自上而下”或“以大脑为中心”的方法进行植入物设计和应用。 结论:人工耳蜗及相关治疗的发展取得了显著进展,但仍有改进空间。未来前景光明,因为有多种有前景的改进可能性,并且许多有才华的团队正在致力于此。
World J Otorhinolaryngol Head Neck Surg. 2018-1-3
Trends Amplif. 2004
Front Bioeng Biotechnol. 2022-6-3
J Acoust Soc Am. 2022-5
EMBnet J. 2022-4
Front Bioeng Biotechnol. 2022-1-24
Front Neurosci. 2021-6-9
Lancet Neurol. 2016-5
Otol Neurotol. 2016-2
Hear Res. 2015-4
Audiol Neurootol. 2014