脂滴与运动神经元病之间新的关联。
Emerging Links between Lipid Droplets and Motor Neuron Diseases.
机构信息
Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh EH8 9XD, UK; Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.
Department of Biology, University of Rochester, Rochester, NY 14627, USA.
出版信息
Dev Cell. 2018 May 21;45(4):427-432. doi: 10.1016/j.devcel.2018.05.002.
Abstract
Lipid droplets (LDs) are ubiquitous fat storage organelles and play key roles in lipid metabolism and energy homeostasis; in addition, they contribute to protein storage, folding, and degradation. However, a role for LDs in the nervous system remains largely unexplored. We discuss evidence supporting an intimate functional connection between LDs and motor neuron disease (MND) pathophysiology, examining how LD functions in systemic energy homeostasis, in neuron-glia metabolic coupling, and in protein folding and clearance may affect or contribute to disease pathology. An integrated understanding of LD biology and neurodegeneration may open the way for new therapeutic interventions.
摘要
脂滴（LDs）是普遍存在的脂肪储存细胞器，在脂质代谢和能量平衡中发挥关键作用；此外，它们还有助于蛋白质储存、折叠和降解。然而，LD 在神经系统中的作用在很大程度上仍未得到探索。我们讨论了支持 LD 与运动神经元疾病（MND）病理生理学之间密切功能联系的证据，研究了 LD 在全身能量平衡、神经元-胶质代谢偶联以及蛋白质折叠和清除中的功能如何影响或导致疾病病理学。对 LD 生物学和神经退行性变的综合理解可能为新的治疗干预措施开辟道路。
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