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Acad Med. 2015 Nov;90(11):1553-60. doi: 10.1097/ACM.0000000000000938.
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The effect of an intense mentoring program on junior investigators' preparation for a patient-oriented clinical research career.一项强化指导计划对初级研究人员开展以患者为导向的临床研究职业生涯准备情况的影响。
Acad Med. 2015 Aug;90(8):1061-6. doi: 10.1097/ACM.0000000000000742.
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Quantifying complexity in translational research: an integrated approach.量化转化研究中的复杂性:一种综合方法。
Int J Health Care Qual Assur. 2014;27(8):760-76. doi: 10.1108/ijhcqa-01-2014-0002.
6
Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program.培训未来的转化研究团队:加州大学戴维斯分校 - HHMI 将医学纳入基础科学计划。
Clin Transl Sci. 2013 Oct;6(5):339-46. doi: 10.1111/cts.12068. Epub 2013 May 15.
7
Expanding assessments of translational research programs: supplementing metrics with value judgments.拓展对转化研究项目的评估:用价值判断补充指标
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8
Common metrics to assess the efficiency of clinical research.评估临床研究效率的常用指标。
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Developing a competency-based educational structure within clinical and translational science.制定临床与转化科学的基于能力的教育结构。
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A framework for training health professionals in implementation and dissemination science.培训实施和传播科学领域卫生专业人员的框架。
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转化研究范式的当前趋势。

The Current Trend of the Translational Research Paradigm.

作者信息

Choi Paul J, Tubbs R Shane, Oskouian Rod J

机构信息

Clinical Anatomy, Seattle Science Foundation.

Neurosurgery, Seattle Science Foundation.

出版信息

Cureus. 2018 Mar 19;10(3):e2340. doi: 10.7759/cureus.2340.

DOI:10.7759/cureus.2340
PMID:29796353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5959726/
Abstract

The translational research paradigm is a process of discovering basic science concepts and applying the knowledge in clinical practice, aiming to improve patient care. The stages involved in the paradigm form a complex network of shared knowledge amongst research collaborators, including patients. This nature of the paradigm allows those involved to work together effectively. However, the translational research paradigm is often overlooked by many scientists, educators, and research institutions. Hence, a large amount of comprehensive and hugely invested research projects fail to make a scientific impact. We aim to outline and describe this paradigm in order to aid in the successful translation of effective research.

摘要

转化研究范式是一个发现基础科学概念并将这些知识应用于临床实践的过程,旨在改善患者护理。该范式所涉及的阶段在包括患者在内的研究合作者之间形成了一个共享知识的复杂网络。这种范式的性质使相关人员能够有效地合作。然而,转化研究范式常常被许多科学家、教育工作者和研究机构忽视。因此,大量全面且投入巨大的研究项目未能产生科学影响。我们旨在概述和描述这一范式,以助力有效研究的成功转化。