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茶多酚抑制副猪嗜血杆菌的生长及毒力相关因子。

Tea polyphenols suppress growth and virulence-related factors of Haemophilus parasuis.

作者信息

Guo Ling, Guo Jing, Liu HuaShan, Zhang Jing, Chen Xiabing, Qiu Yinsheng, Fu Shulin

机构信息

Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan 430023, PR China.

Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan 430208, China.

出版信息

J Vet Med Sci. 2018 Jul 12;80(7):1047-1053. doi: 10.1292/jvms.18-0085. Epub 2018 May 22.

DOI:10.1292/jvms.18-0085
PMID:29798967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6068306/
Abstract

The bacterium Haemophilus parasuis (H. parasuis) is the primary cause of Glässer's disease. Currently, there are no effective vaccines that can confer protection against all H. parasuis serovars. Therefore, the present study aimed to investigate the effect of tea polyphenols on growth, expression of virulence-related factors, and biofilm formation of H. parasuis, as well as to evaluate their protective effects against H. parasuis challenge. Our findings demonstrated that tea polyphenols can inhibit H. parasuis growth in a dose-dependent manner and attenuate the biofilm formation of H. parasuis. In addition, tea polyphenols exerted inhibitory effects on the expression of H. parasuis virulence-related factors. Moreover, tea polyphenols could confer protection against a lethal dose of H. parasuis and can reduce pathological tissue damage induced by H. parasuis. In summary, our findings demonstrated the promising use of tea polyphenols as a novel treatment for H. parasuis infection in pigs.

摘要

副猪嗜血杆菌是格拉泽氏病的主要病因。目前，尚无有效的疫苗能够对所有副猪嗜血杆菌血清型提供保护。因此，本研究旨在探讨茶多酚对副猪嗜血杆菌生长、毒力相关因子表达及生物膜形成的影响，并评估其对副猪嗜血杆菌攻击的保护作用。我们的研究结果表明，茶多酚能够以剂量依赖的方式抑制副猪嗜血杆菌的生长，并减弱其生物膜形成。此外，茶多酚对副猪嗜血杆菌毒力相关因子的表达具有抑制作用。而且，茶多酚能够对致死剂量的副猪嗜血杆菌提供保护，并可减轻副猪嗜血杆菌诱导的病理组织损伤。总之，我们的研究结果表明，茶多酚有望作为一种新型疗法用于治疗猪的副猪嗜血杆菌感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/b0c9d35196b7/jvms-80-1047-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/7a1f0e7766fa/jvms-80-1047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/004ad004b5a3/jvms-80-1047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/b7d3c94723c2/jvms-80-1047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/e0727aebac6b/jvms-80-1047-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/a5206d5df1fb/jvms-80-1047-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/b0c9d35196b7/jvms-80-1047-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/7a1f0e7766fa/jvms-80-1047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/004ad004b5a3/jvms-80-1047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/b7d3c94723c2/jvms-80-1047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/e0727aebac6b/jvms-80-1047-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/a5206d5df1fb/jvms-80-1047-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3813/6068306/b0c9d35196b7/jvms-80-1047-g006.jpg

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