Nano-Biotechnology (NABI) Laboratory, Rizzoli RIT Department, Rizzoli Orthopaedic Institute, Via di Barbiano 1/10, Bologna, 40136, Italy.
Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital and Faculty of Medicine, Technische Universität Dresden, Fetscherstr. 73, Dresden, 01307, Germany.
J Mater Sci Mater Med. 2018 May 26;29(6):74. doi: 10.1007/s10856-018-6074-0.
Current therapeutic strategies for osteochondral restoration showed a limited regenerative potential. In fact, to promote the growth of articular cartilage and subchondral bone is a real challenge, due to the different functional and anatomical properties. To this purpose, alginate is a promising biomaterial for a scaffold-based approach, claiming optimal biocompatibility and good chondrogenic potential. A previously developed mineralized alginate scaffold was investigated in terms of the ability to support osteochondral regeneration both in a large and medium size animal model. The results were evaluated macroscopically and by microtomography, histology, histomorphometry, and immunohistochemical analysis. No evidence of adverse or inflammatory reactions was observed in both models, but limited subchondral bone formation was present, together with a slow scaffold resorption time.The implantation of this biphasic alginate scaffold provided partial osteochondral regeneration in the animal model. Further studies are needed to evaluate possible improvement in terms of osteochondral tissue regeneration for this biomaterial.
目前的骨软骨修复治疗策略显示出有限的再生潜力。事实上，由于功能和解剖特性的不同，促进关节软骨和软骨下骨的生长是一个真正的挑战。为此，藻酸盐是一种很有前途的支架基生物材料，具有最佳的生物相容性和良好的软骨生成潜力。以前开发的矿化藻酸盐支架在大型和中型动物模型中均具有支持骨软骨再生的能力。通过宏观和微断层扫描、组织学、组织形态计量学和免疫组织化学分析来评估结果。在这两种模型中均未观察到不良反应或炎症反应的证据，但存在有限的软骨下骨形成，以及较慢的支架吸收时间。这种双相藻酸盐支架的植入为动物模型提供了部分骨软骨再生。需要进一步研究来评估这种生物材料在骨软骨组织再生方面的可能改善。
