Bartholomew C, Charles W, Saxinger C, Blattner W, Robert-Guroff M, Raju C, Ratan P, Ince W, Quamina D, Basdeo-Maharaj K
Br Med J (Clin Res Ed). 1985 Apr 27;290(6477):1243-6. doi: 10.1136/bmj.290.6477.1243.
Adult T cell leukaemia/lymphoma was first recognised as a clinical entity in southwest Japan. Subsequently the Caribbean has been found to be another area where the disease is endemic, and sporadic cases have been identified in different parts of the world. The human T cell leukaemia/lymphoma virus (HTLV-I) is causally related to adult T cell leukaemia/lymphoma. A subgroup of HTLV, designated HTLV-III, has recently been isolated from many patients with the acquired immunodeficiency syndrome (AIDS) and preAIDS, and there is now evidence that this variant is the primary cause of AIDS. This is the first report from Trinidad to describe 12 cases of adult T cell leukaemia/lymphoma and 14 of AIDS. All were in patients of African descent. No cases were seen in subjects of East Indian descent, who, like those of African descent, comprise as much as 40% of the population. West Indians of African descent may have increased susceptibility to infection with both HTLV-I and HTLV-III.
成人T细胞白血病/淋巴瘤最初是在日本西南部作为一种临床实体被识别出来的。随后发现加勒比地区是该疾病的另一个流行地区，并且在世界不同地区也发现了散发病例。人类T细胞白血病/淋巴瘤病毒（HTLV-I）与成人T细胞白血病/淋巴瘤存在因果关系。HTLV的一个亚组，称为HTLV-III，最近已从许多获得性免疫缺陷综合征（AIDS）和艾滋病前期患者中分离出来，现在有证据表明这种变体是AIDS的主要病因。这是特立尼达第一份描述12例成人T细胞白血病/淋巴瘤和14例艾滋病病例的报告。所有病例均为非洲裔患者。在东印度裔受试者中未发现病例，东印度裔和非洲裔一样，占人口的40%。非洲裔西印度人可能对HTLV-I和HTLV-III感染的易感性增加。
