Opt Lett. 2018 Jun 1;43(11):2470-2473. doi: 10.1364/OL.43.002470.
Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT images. We demonstrate our technique by performing an ILM peel in ex vivo eyes using low ICG concentrations and laser powers. These results establish the feasibility of PT-OCT for intraoperative guidance during retinal surgery.
吲哚菁绿（ICG）在手术中常用于染色内界膜（ILM），并在白光手术显微镜下提供对比度。虽然光学相干断层扫描（OCT）在眼科手术中的术中成像翻译增强了可视化效果，但 ILM 仍然难以与视网膜下结构区分，ICG 也不会提供额外的 OCT 对比度。我们提出了光热 OCT（PT-OCT）用于视网膜 OCT 图像上 ICG 的高特异性检测。我们通过在离体眼睛中使用低浓度的 ICG 和激光功率来进行 ILM 剥离来证明我们的技术。这些结果确立了 PT-OCT 在视网膜手术中的术中指导的可行性。
