Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
Institutes of Biomedical Sciences, Fudan University, 131 Dong An Road, Shanghai 200032, China.
Biomed Res Int. 2018 May 15;2018:4793971. doi: 10.1155/2018/4793971. eCollection 2018.
MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in , as well as , tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
微小 RNA 在癌症的发展中发挥着重要作用，可能成为有前途的治疗靶点。在我们之前的工作中，miR-219-5p 被鉴定为 HCC 中重要的转移相关 microRNA 之一。在这里，我们证明了 miR-219-5p 在 HCC 组织中表达上调，与血管侵犯和预后不良有关。在多变量分析中，miR-219-5p 被确定为 HCC 患者的独立预后指标。功能机制分析表明，miR-219-5p 促进 HCC 细胞在体内的增殖和侵袭，以及在携带人 HCC 肿瘤的裸鼠模型中的肿瘤生长和转移。此外，钙粘蛋白 1 (CDH1) 被揭示为 HCC 细胞中 miR-219-5p 的下游靶标。总之，miR-219-5p 通过调节 CDH1 促进 HCC 的肿瘤生长和转移，可以作为 HCC 患者的预后标志物。
