Department of Engineering, University of Campania "Luigi Vanvitelli", via Roma 29, 81031 Aversa, Italy.
Copernico S.r.l., Via Monte Hermada 75, 33100 Udine, Italy.
Sensors (Basel). 2018 Jun 5;18(6):1836. doi: 10.3390/s18061836.
A novel Molecularly Imprinted Polymer (MIP) able to bind perfluorinated compounds, combined with a surface plasmon resonance (SPR) optical fiber platform, is presented. The new MIP receptor has been deposited on a D-shaped plastic optical fiber (POF) covered with a photoresist buffer layer and a thin gold film. The experimental results have shown that the developed SPR-POF-MIP sensor makes it possible to selectively detect the above compounds. In this work, we present the results obtained with perfluorooctanoate (PFOA) compound, and they hold true when obtained with a perfluorinated alkylated substances (PFAs) mixture sample. The sensor's response is the same for PFOA, perfluorooctanesulfonate (PFOS) or PFA contaminants in the C₄⁻C range. We have also tested a sensor based on a non-imprinted polymer (NIP) on the same SPR in a D-shaped POF platform. The limit of detection (LOD) of the developed chemical sensor was 0.13 ppb. It is similar to the one obtained by the configuration based on a specific antibody for PFOA/PFOS exploiting the same SPR-POF platform, already reported in literature. The advantage of an MIP receptor is that it presents a better stability out of the native environment, very good reproducibility, low cost and, furthermore, it can be directly deposited on the gold layer, without modifying the metal surface by functionalizing procedures.
一种新型的能够结合全氟化合物的分子印迹聚合物（MIP），与表面等离子体共振（SPR）光纤平台相结合，被提了出来。新型 MIP 受体被沉积在 D 型塑料光纤（POF）上，该光纤覆盖有光致抗蚀剂缓冲层和薄金膜。实验结果表明，所开发的 SPR-POF-MIP 传感器能够选择性地检测上述化合物。在这项工作中，我们展示了用全氟辛酸（PFOA）化合物获得的结果，当用全氟烷基化物质（PFAs）混合物样品获得时，结果也是如此。对于 PFOA、全氟辛烷磺酸（PFOS）或 C₄⁻C 范围内的 PFA 污染物，传感器的响应是相同的。我们还在 D 型 POF 平台上的相同 SPR 上测试了基于非印迹聚合物（NIP）的传感器。所开发的化学传感器的检测限（LOD）为 0.13 ppb。这与文献中已经报道的基于 PFOA/PFOS 特异性抗体的相同 SPR-POF 平台的配置所获得的 LOD 相似。MIP 受体的优点是，它在非天然环境下具有更好的稳定性、非常好的重现性、低成本，而且它可以直接沉积在金层上，而不需要通过功能化程序来修饰金属表面。
