Intensive Care Unit, Hospital Universitário, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Av Universitária, 1105, Criciúma, SC, 88806000, Brazil.
Mol Neurobiol. 2019 Jan;56(1):763-767. doi: 10.1007/s12035-018-1166-x. Epub 2018 Jun 7.
Persistent inflammation in intensive care unit (ICU) survivors is associated with higher long-term mortality and poorer mobility. However, it is unknown if inflammatory markers are associated with other dysfunctions observed in survivors of critical illness. Thus, it was investigated if plasma levels of interleukin (IL)-6 and IL-10 at hospital discharge were associated with long-term functional and cognitive performance after ICU discharge. Adult patients admitted for > 48 h to a 20-bed mixed ICU in a University Hospital had blood collected within 48 h before hospital discharge to measure IL-6 and IL-10 levels. After a median time of 48 months, cognitive status was determined by the Mini-Mental State Examination (MMSE), and functional status was determined by the Barthel Index. Patients at the higher 25th percentile of both IL-6 and IL-10 had a worse long-term cognitive performance, but not worse functional status, even when adjusted for confounders after long-term follow-up. In conclusion, elevated circulating IL-6 and IL-10 concentrations at hospital discharge were associated with long-term cognitive dysfunction in ICU survivors.
重症监护病房（ICU）幸存者持续存在炎症与长期死亡率较高和活动能力较差有关。然而，目前尚不清楚炎症标志物是否与危重病幸存者中观察到的其他功能障碍有关。因此，研究人员调查了 ICU 出院时的血浆白细胞介素（IL）-6 和 IL-10 水平是否与出院后的长期功能和认知表现有关。在一家大学医院的 20 张混合 ICU 中住院超过 48 小时的成年患者在出院前 48 小时内采集血液以测量 IL-6 和 IL-10 水平。中位时间为 48 个月后，通过 Mini-Mental State Examination（MMSE）确定认知状态，通过 Barthel 指数确定功能状态。在长期随访后，即使调整了混杂因素，较高的 25 百分位 IL-6 和 IL-10 的患者也有更差的长期认知表现，但功能状态没有更差。总之，出院时循环中升高的 IL-6 和 IL-10 浓度与 ICU 幸存者的长期认知功能障碍有关。
