Faculty of Physics , M. V. Lomonosov Moscow State University , 119991 Moscow , Russia.
Department of Pharmaceutical analysis, School of Pharmacy, and The State Key Laboratory of Cancer Biology (CBSKL) , Fourth Military Medical University , 169th Changle West Road , 710032 Xi'an , Shaanxi , China.
ACS Appl Mater Interfaces. 2018 Jul 18;10(28):23529-23538. doi: 10.1021/acsami.8b04557. Epub 2018 Jul 2.
Porous silicon (PSi) has attracted wide interest as a potential material for various fields of nanomedicine. However, until now, the application of PSi in photothermal therapy has not been successful due to its low photothermal conversion efficiency. In the present study, biodegradable black PSi (BPSi) nanoparticles were designed and prepared via a high-yield and simple reaction. The PSi nanoparticles possessed a low band gap of 1.34 eV, a high extinction coefficient of 13.2 L/g/cm at 808 nm, a high photothermal conversion efficiency of 33.6%, good photostability, and a large surface area. The nanoparticles had not only excellent photothermal properties surpassing most of the present inorganic photothermal conversion agents (PCAs) but they also displayed good biodegradability, a common problem encountered with the inorganic PCAs. The functionality of the BPSi nanoparticles in photothermal therapy was verified in tumor-bearing mice in vivo. These results showed clearly that the photothermal treatment was highly efficient to inhibit tumor growth. The designed PCA material of BPSi is robust, easy to prepare, biocompatible, and therapeutically extremely efficient and it can be integrated with several other functionalities on the basis of simple silicon chemistry.
多孔硅（PSi）作为一种潜在的纳米医学各领域的材料，已经引起了广泛的关注。然而，到目前为止，由于 PSi 的光热转换效率低，其在光热治疗中的应用尚未成功。在本研究中，通过一种高产率且简单的反应，设计并制备了可生物降解的黑色 PSi（BPSi）纳米颗粒。PSi 纳米颗粒具有低带隙 1.34eV、808nm 处的高光吸收系数 13.2L/g/cm、高光热转换效率 33.6%、良好的光稳定性和大的比表面积。这些纳米颗粒不仅具有优异的光热性能，超过了大多数现有的无机光热转换剂（PCAs），而且还表现出良好的生物降解性，这是无机 PCAs 常见的问题。BPSi 纳米颗粒在肿瘤荷瘤小鼠体内的光热治疗功能得到了验证。这些结果清楚地表明，光热治疗对抑制肿瘤生长非常有效。所设计的 BPSi PCA 材料坚固、易于制备、生物相容，并且在基于简单硅化学的基础上具有极高的治疗效率，它可以与其他几种功能结合。
