Yu Hao-Bing, Jiao Heng, Zhu Yu-Ping, Zhang Jian-Peng, Lu Xiao-Ling, Liu Xiao-Yu
College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University , Shanghai 200433 , China.
Marine Biopharmaceutical Institute, Second Military Medical University , Shanghai 200433 , China.
J Asian Nat Prod Res. 2019 Oct;21(10):961-969. doi: 10.1080/10286020.2018.1482880. Epub 2018 Jun 18.
Two new cyclohexanone derivatives, nectriatones A-B (-), and one new natural product, nectriatone C (), together with three known phenolic sesquiterpene derivatives (-), were isolated from the culture of sp. B-13 obtained from high-latitude soil of the Arctic. The structures of all compounds were unambiguously elucidated by extensive spectroscopic analysis, as well as by comparison with the literature. These compounds were evaluated in cytotoxic and antibacterial activities. Compounds - showed cytotoxicities against SW1990, HCT-116, MCF-7, and K562 cells, with IC values in the range of 0.43 to 42.64 μM. Only compound exhibited antibacterial activity against , , and (MIC 4.0, 2.0, and 4.0 μg/ml, respectively).
从北极高纬度土壤中获得的链格孢属真菌B-13的培养物中，分离出两种新的环己酮衍生物，链格孢酮A-B（-），一种新的天然产物，链格孢酮C（），以及三种已知的酚类倍半萜衍生物（-）。通过广泛的光谱分析以及与文献比较，明确阐明了所有化合物的结构。对这些化合物进行了细胞毒性和抗菌活性评估。化合物 - 对SW1990、HCT-116、MCF-7和K562细胞表现出细胞毒性，IC值在0.43至42.64 μM范围内。只有化合物 对 、 和 表现出抗菌活性（MIC分别为4.0、2.0和4.0 μg/ml）。
