Tien Dat Trinh, Kotani Tomomi, Yamamoto Eiko, Shibata Kiyosumi, Moriyama Yoshinori, Tsuda Hiroyuki, Yamashita Mamoru, Kajiyama Hiroaki, Duc Thien Minh Dien, Quang Thanh Le, Kikkawa Fumitaka
Delivery Room, Tu Du Hospital, Ho Chi Ming City, Vietnam.
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya J Med Sci. 2018 May;80(2):241-247. doi: 10.18999/nagjms.80.2.241.
Dengue fever during pregnancy is an expanding issue in Southeast Asia; however, the knowledge of adverse effects on mothers and neonates remains limited. Therefore, we aimed to determine the impact of dengue fever. The clinical information of 20 patients of dengue fever during pregnancy in Vietnam from January 1, 2015 to December 31, 2015 was collected and their outcomes were retrospectively investigated. A total of 18 patients (90%) presented with positivity of nonstructural protein 1, and a primary infection. Additionally, 4 patients (20%) had preterm deliveries and 1 (5%) had a stillborn child. All live-born neonates were discharged from the hospital uneventfully. Also, 6 patients (30%) required platelet transfusion and 3 of them received transfusion before delivery, but there were no maternal death. In addition, 3 cases of patients (15%) developed to postpartum hemorrhage (PPH), and their platelet concentrations were significantly lower than those of patients without PPH [90.0 (19.0 - 374.0) × 10 vs. 40.0 (12.0 - 57.0) × 10 cell/μl, = 0.001]. In addition, patients with PPH also presented with elevated liver enzymes. Pregnant patients with low platelet counts should be recognized as being at high risk for PPH.
孕期登革热在东南亚地区是一个日益严重的问题；然而，关于其对母亲和新生儿不良影响的了解仍然有限。因此，我们旨在确定登革热的影响。收集了2015年1月1日至2015年12月31日期间越南20例孕期登革热患者的临床信息，并对其结局进行回顾性研究。共有18例患者（90%）非结构蛋白1检测呈阳性，且为初次感染。此外，4例患者（20%）发生早产，1例（5%）出现死产。所有存活新生儿均顺利出院。另外，6例患者（30%）需要输注血小板，其中3例在分娩前接受了输血，但无孕产妇死亡。此外，3例患者（15%）发生了产后出血（PPH），其血小板浓度显著低于未发生PPH的患者[90.0（19.0 - 374.0）×10⁹ 对 40.0（12.0 - 57.0）×10⁹ 细胞/μl，P = 0.001]。此外，发生PPH的患者还出现肝酶升高。血小板计数低的孕妇应被视为发生PPH的高危人群。
