人类宫颈肿瘤中的乳头瘤病毒基因组：其转录活性分析
Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity.
作者信息
Lehn H, Krieg P, Sauer G
出版信息
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5540-4. doi: 10.1073/pnas.82.16.5540.
Four of six human cervical carcinoma biopsies were shown to contain the DNA of the human papillomavirus type 16 (HPV-16) covalently linked with the tumor cell DNA. HPV-16-specific mRNA species were observed in only one of the four tumors. No such sequences were found in the three other specimens in conditions that permitted the detection of less than one mRNA molecule per cell. It is concluded that maintenance of the malignant nature of these cervical tumors does not depend on the continuous transcriptional activity of HPV-16.
在六份人宫颈癌活检样本中，有四份被证明含有与肿瘤细胞DNA共价连接的16型人乳头瘤病毒（HPV - 16）的DNA。仅在这四个肿瘤中的一个中观察到了HPV - 16特异性的mRNA种类。在其他三个样本中，在允许检测到每个细胞少于一个mRNA分子的条件下未发现此类序列。得出的结论是，这些宫颈肿瘤的恶性性质的维持并不依赖于HPV - 16的持续转录活性。
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