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1
Regions on plasmid pCU1 required for the killing of Klebsiella pneumoniae.质粒pCU1上杀死肺炎克雷伯菌所需的区域。
J Bacteriol. 1985 Sep;163(3):1296-9. doi: 10.1128/jb.163.3.1296-1299.1985.
2
A demonstration that pCU1 tra gene products are not required in the killing of Klebsiella pneumoniae.一项关于在杀灭肺炎克雷伯菌过程中不需要pCU1 tra基因产物的证明。
Plasmid. 1988 Mar;19(2):161-3. doi: 10.1016/0147-619x(88)90054-6.
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Isolation and characterization of kikA, a region on IncN group plasmids that determines killing of Klebsiella oxytoca.IncN 组质粒上决定杀克雷伯氏菌的 kikA 区域的分离与特性分析
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4
Cloning of a plasmid region specifying the N transfer system of bacterial conjugation in Escherichia coli.大肠杆菌中决定细菌接合作用N转移系统的质粒区域的克隆
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EMBO J. 1983;2(10):1831-8. doi: 10.1002/j.1460-2075.1983.tb01666.x.
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Structure and mode of action of kikA, a genetic region lethal to Klebsiella oxytoca and associated with conjugative antibiotic-resistance plasmids of the IncN group.
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Conjugative delivery of toxin genes and confers synergistic killing of bacterial recipients.毒素基因的接合传递并赋予对细菌受体的协同杀伤作用。
J Bacteriol. 2025 Jul 24;207(7):e0016825. doi: 10.1128/jb.00168-25. Epub 2025 Jul 3.
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Two pKM101-encoded proteins, the pilus-tip protein TraC and Pep, assemble on the Escherichia coli cell surface as adhesins required for efficient conjugative DNA transfer.两个 pKM101 编码蛋白，菌毛尖端蛋白 TraC 和 Pep，作为大肠杆菌细胞表面上用于有效接合性 DNA 转移的黏附素组装。
Mol Microbiol. 2019 Jan;111(1):96-117. doi: 10.1111/mmi.14141. Epub 2018 Oct 21.
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Host Ranges of the IncN Group Plasmid pCU1 and Its Minireplicon in Gram-Negative Purple Bacteria.革兰氏阴性紫色细菌中 IncN 组质粒 pCU1 及其复制子的宿主范围。
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Transfer functions of the conjugative integrating element pSAM2 from Streptomyces ambofaciens: characterization of a kil-kor system associated with transfer.来自产二素链霉菌的接合整合元件pSAM2的转移功能：与转移相关的一个致死-抑制系统的特性
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Lethality and survival of Klebsiella oxytoca evoked by conjugative IncN group plasmids.接合型IncN群质粒引发的产酸克雷伯菌的致死率与存活率
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7
N conjugative transfer system of plasmid pCU1.质粒pCU1的N接合转移系统。
J Bacteriol. 1985 Sep;163(3):1229-36. doi: 10.1128/jb.163.3.1229-1236.1985.
8
Isolation and characterization of kikA, a region on IncN group plasmids that determines killing of Klebsiella oxytoca.IncN 组质粒上决定杀克雷伯氏菌的 kikA 区域的分离与特性分析
J Bacteriol. 1992 May;174(9):3070-7. doi: 10.1128/jb.174.9.3070-3077.1992.
9
Mutational analysis of essential IncP alpha plasmid transfer genes traF and traG and involvement of traF in phage sensitivity.IncPα 接合质粒必需转移基因 traF 和 traG 的突变分析以及 traF 在噬菌体敏感性中的作用
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本文引用的文献

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Broad host range plasmid RK2 encodes multiple kil genes potentially lethal to Escherichia coli host cells.广宿主范围质粒RK2编码多个对大肠杆菌宿主细胞有潜在致死性的kil基因。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1935-9. doi: 10.1073/pnas.79.6.1935.
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Killing of Klebsiella pneumoniae mediated by conjugation with bacteria carrying antibiotic-resistance plasmids of the group N.通过与携带N组抗生素抗性质粒的细菌接合介导的肺炎克雷伯菌杀灭作用
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Inverted repeats in the DNA of plasmid pCU1.质粒pCU1 DNA中的反向重复序列。
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Deletion mapping of kil and kor functions in the trfA and trfB regions of broad host range plasmid RK2.广宿主范围质粒RK2的trfA和trfB区域中kil和kor功能的缺失图谱分析
Mol Gen Genet. 1983;190(2):245-54. doi: 10.1007/BF00330647.
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Physical and genetic organization of the IncN-group plasmid pCU1.IncN 群质粒 pCU1 的物理和遗传组织
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Characteristics of PRD1, a plasmid-dependent broad host range DNA bacteriophage.PDR1的特性，一种依赖质粒的广泛宿主范围DNA噬菌体。
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10
Identification of pKM101-encoded loci specifying potentially lethal gene products.鉴定由pKM101编码的、指定潜在致死基因产物的基因座。
J Bacteriol. 1985 Jan;161(1):417-24. doi: 10.1128/jb.161.1.417-424.1985.

质粒pCU1上杀死肺炎克雷伯菌所需的区域。

Regions on plasmid pCU1 required for the killing of Klebsiella pneumoniae.

作者信息

Thatte V, Gill S, Iyer V N

出版信息

J Bacteriol. 1985 Sep;163(3):1296-9. doi: 10.1128/jb.163.3.1296-1299.1985.

DOI:10.1128/jb.163.3.1296-1299.1985
PMID:2993244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC219280/
Abstract

Plasmid pCU1 was Kik+ (promotes killing of Klebsiella pneumoniae). All Tn5 insertions within the tra region of pCU1 were Kik-. Two other regions, kikA and kikB, were needed. They may be separated on different plasmids, but both must be mobilized into Klebsiella pneumoniae. Establishment of one kik region in K. pneumoniae followed by receipt of the second did not lead to killing. Kik was therefore intracellular and required concerted and transient action of both regions.

摘要

质粒pCU1是Kik+（促进肺炎克雷伯菌的杀伤）。pCU1转移区（tra region）内的所有Tn5插入突变体都是Kik-。还需要另外两个区域，即kikA和kikB。它们可能位于不同的质粒上，但两者都必须转移到肺炎克雷伯菌中。在肺炎克雷伯菌中先建立一个kik区域，随后再获得第二个区域，并不会导致杀伤作用。因此，Kik作用于细胞内，并且需要两个区域协同且短暂地发挥作用。