Obayo Siraji, Lukwago Luswa, Orem Jackson, Faulx Ashley L, Probert Christopher S
Mbarara University Teaching Hospital, Mbarara, Uganda and the Uganda Cancer Institute, Kampala, Uganda.
Ministry of Health Department of Epidemiology, Kampala Uganda.
Afr Health Sci. 2017 Dec;17(4):1051-1058. doi: 10.4314/ahs.v17i4.13.
There is a paucity of published data regarding the trend and distribution of gastrointestinal malignancies in Uganda.
To study the trend and distribution of gastrointestinal malignancies over a 10 year period at five regional referral hospitals in Uganda.
Patient's charts with histologically confirmed diagnoses of gastrointestinal malignancies for the period 2002-2011 were identified. Case information, which included age at diagnosis, sex, and year of diagnosis, primary anatomic site of the tumour and hospitals attended, was retrospectively abstracted. Patient's clinical and demographic features were compared.
Oesophageal cancer was the most common (28.8%) followed by liver (25.8%), stomach (18.4%) and colorectal (14.3%). The mean age at diagnosis for all the cancers was not significantly different in both sexes 54.1, (SD16.1) versus 53.6, (SD 14.7). The highest mean annual number of cases of oesophageal and stomach cancers was 21.8, (SD 15.5) and 16.6, (SD 13.0) respectively from Mbarara Hospital; Lacor had the highest mean annual number of liver cancer cases (21, SD 17.7) followed by Mbale (11.4, SD 8.3). The mean annual number of colorectal cancers was highest in Mbale Hospital (10.3, SD 8.1) followed by Lacor (4.9, SD 3.9). The distribution of oesophageal, liver, stomach and colorectal cancers diagnosed per year across the five referral hospitals was different, P<0.001.
Oesophageal, liver, stomach and colorectal cancer remain the most common gastrointestinal malignancies and their rate is increasing in Uganda. There is a need for awareness, endoscopic and radiological assessment of symptomatic individuals and a need for screening of high index patients.
关于乌干达胃肠道恶性肿瘤的趋势和分布，已发表的数据很少。
研究乌干达五家区域转诊医院10年间胃肠道恶性肿瘤的趋势和分布。
确定2002年至2011年期间经组织学确诊为胃肠道恶性肿瘤的患者病历。回顾性提取病例信息，包括诊断时的年龄、性别、诊断年份、肿瘤的主要解剖部位和就诊医院。比较患者的临床和人口统计学特征。
食管癌最常见（28.8%），其次是肝癌（25.8%）、胃癌（18.4%）和结直肠癌（14.3%）。所有癌症诊断时的平均年龄在两性中无显著差异，分别为54.1（标准差16.1）和53.6（标准差14.7）。姆巴拉拉医院食管癌和胃癌的年平均病例数最高，分别为21.8（标准差15.5）和16.6（标准差13.0）；拉科尔医院肝癌的年平均病例数最高（21，标准差17.7），其次是姆巴莱（11.4，标准差8.3）。姆巴莱医院结直肠癌的年平均病例数最高（10.3，标准差8.1），其次是拉科尔（4.9，标准差3.9）。五家转诊医院每年诊断的食管癌、肝癌、胃癌和结直肠癌的分布不同，P<0.001。
食管癌、肝癌、胃癌和结直肠癌仍然是乌干达最常见的胃肠道恶性肿瘤，且发病率在上升。有必要提高认识，对有症状的个体进行内镜和放射学评估，并对高风险患者进行筛查。
