Division of Cardiovascular Medicine, University of California San Diego, 9300 Campus Point Drive MC 7411, La Jolla, CA, 92037, USA.
Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, USA.
Drugs. 2018 Jul;78(10):983-994. doi: 10.1007/s40265-018-0931-5.
Postural orthostatic tachycardia syndrome (POTS) is a debilitating disease that predominantly affects young women. It is a multifactorial disorder that is characterized by severe tachycardia and orthostatic intolerance. Patients with POTS experience a variety of cardiac, neurological, and immunological symptoms that significantly reduce quality of life. In this review, a comprehensive framework is provided to aid in helping identify and treat patients with POTS. Given its heterogenous nature, it is crucial to understand each component of POTS in relation to one another instead of distinct parts. The framework highlights the overlap among the five main subtypes of POTS based on its pathophysiology (neuropathic, hypovolemic, primary hyperadrenergic, joint-hypermobility-related, and immune-related). Emphasis is placed on incorporating a multidisciplinary approach when treating patients with POTS, especially with a new focus towards immunotherapy. Although research has advanced our knowledge of POTS, there is still a critically unmet need to further our understanding and provide patients with the relief they need.
体位性心动过速综合征（POTS）是一种主要影响年轻女性的使人虚弱的疾病。它是一种多因素疾病，其特征是严重的心动过速和直立不耐受。患有 POTS 的患者会出现各种心脏、神经和免疫症状，大大降低了生活质量。在这篇综述中，提供了一个全面的框架来帮助识别和治疗 POTS 患者。鉴于其异质性，了解 POTS 的每个组成部分彼此相关而不是独立的部分至关重要。该框架根据其病理生理学（神经型、低血容量型、原发性高肾上腺素能型、关节过度活动相关型和免疫相关型）突出了 POTS 五个主要亚型之间的重叠。在治疗 POTS 患者时，强调采用多学科方法，尤其是新的免疫疗法。尽管研究已经提高了我们对 POTS 的认识，但仍迫切需要进一步了解该病，并为患者提供他们所需的缓解。
