School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD, Australia; Menzies Health Institute Queensland (MHIQ), Griffith University, Gold Coast, QLD, Australia; Department of Prosthodontics, School of Stomatology, Capital Medical University, Beijing, People's Republic of China.
School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD, Australia; Menzies Health Institute Queensland (MHIQ), Griffith University, Gold Coast, QLD, Australia; The University of Queensland, School of Dentistry, Herston, QLD 4006, Australia.
J Colloid Interface Sci. 2018 Nov 1;529:452-463. doi: 10.1016/j.jcis.2018.06.004. Epub 2018 Jun 4.
Electrochemically anodized titanium surfaces with titania nanostructures (TNS; nanopores, nanotubes, etc.) have been widely applied as therapeutic bone/dental implant modifications. Despite the numerous advancements in the field of electrochemical anodization (EA), in terms of translation into the current implant market, research gaps in this domain include the lack of fabrication optimization, performed on a substrate of conventional implant surface/geometry, and inadequate mechanical stability. In the current study, we investigate the role of substrate pre-treatment on achieving desired nanotopographies for the purpose of reproducing optimized nanostructures on the complex geometry of commercial implant surfaces, as well as in-depth mechanical stability testing of these nano-engineered coatings. The results confirmed that: (a) substrate polishing/smoothening may be insignificant with respect to fabrication of well-ordered and high quality TNS on micro-rough implants with preserved underlying micro-roughness; (b) optimized outcomes can be successfully translated onto complex geometries characteristic of the current implant market, including dental implant abutments and screws (also applicable to a wider implant market including orthopaedics); (c) mechanical stability testing revealed improved modulus and hardness values as compared to conventional nanotubes/pores. We believe that such optimization advances the existing knowledge of titanium anodization and anodized implants towards integration into the current implant market and successful clinical translation.
经过电化学阳极氧化处理后的具有二氧化钛纳米结构（TNS；纳米孔、纳米管等）的钛表面已被广泛应用于治疗性骨/牙科植入物的修饰。尽管电化学阳极氧化（EA）领域取得了众多进展，但就当前植入物市场而言，该领域的研究仍存在一些空白，包括缺乏在传统植入物表面/几何形状的基础上进行的制造优化，以及机械稳定性不足。在本研究中，我们研究了基底预处理在实现所需纳米形貌方面的作用，目的是在商业植入物表面的复杂几何形状上重现优化的纳米结构，并对这些纳米工程涂层进行深入的机械稳定性测试。结果证实：（a）对于在具有保留的底层微观粗糙度的微粗糙植入物上制造有序且高质量的 TNS，基底抛光/平滑处理可能不重要；（b）优化结果可以成功转化为当前植入物市场的复杂几何形状，包括牙科植入物基台和螺丝（也适用于更广泛的植入物市场，包括矫形）；（c）机械稳定性测试显示与传统纳米管/孔相比，其模量和硬度值有所提高。我们相信，这种优化将现有的钛阳极氧化和阳极氧化植入物知识推进到当前植入物市场的整合和成功的临床转化。
