Chopra Divya, Gulati Karan, Ivanovski Sašo
The University of Queensland, School of Dentistry, Herston, QLD 4006, Australia.
Nanomaterials (Basel). 2021 Mar 29;11(4):868. doi: 10.3390/nano11040868.
Anodization enables fabrication of controlled nanotopographies on Ti implants to offer tailorable bioactivity and local therapy. However, anodization of Zr implants to fabricate ZrO nanostructures remains underexplored and are limited to the modification of easy-to-manage flat Zr foils, which do not represent the shape of clinically used implants. In this pioneering study, we report extensive optimization of various nanostructures on implant-relevant micro-rough Zr curved surfaces, bringing this technology closer to clinical translation. Further, we explore the use of sonication to remove the top nanoporous layer to reveal the underlying nanotubes. Nano-engineered Zr surfaces can be applied towards enhancing the bioactivity and therapeutic potential of conventional Zr-based implants.
阳极氧化能够在钛植入物上制造可控的纳米拓扑结构，以提供可定制的生物活性和局部治疗效果。然而，对锆植入物进行阳极氧化以制造氧化锆纳米结构的研究仍未充分开展，且仅限于对易于处理的扁平锆箔进行改性，而这些锆箔并不代表临床使用的植入物的形状。在这项开创性研究中，我们报告了在与植入物相关的微粗糙锆曲面上对各种纳米结构进行的广泛优化，使这项技术更接近临床应用。此外，我们探索了使用超声处理去除顶部纳米多孔层以露出下层纳米管的方法。纳米工程化的锆表面可用于增强传统锆基植入物的生物活性和治疗潜力。
