嗜热菌蛋白酶有限水解使兔肌肉磷酸甘油酸变位酶失活
Inactivation of rabbit muscle phosphoglycerate mutase by limited proteolysis with thermolysin.
作者信息
Price N C, Duncan D, McAlister J W
出版信息
Biochem J. 1985 Jul 1;229(1):167-71. doi: 10.1042/bj2290167.
Abstract
Rabbit muscle phosphoglycerate mutase is inactivated by proteolysis with thermolysin. Inactivation is correlated with the breakage of one (or a few) bond(s) near one end of the polypeptide chain. There is no change in the overall conformation, quaternary structure or binding to Cibacron Blue on proteolysis. The possible analogy with the existence of a flexible tail in the yeast enzyme is discussed.
摘要
兔肌肉磷酸甘油酸变位酶可被嗜热菌蛋白酶进行蛋白水解失活。失活与多肽链一端附近一个（或几个）键的断裂相关。蛋白水解后，其整体构象、四级结构或与汽巴蓝的结合均无变化。文中讨论了与酵母酶中存在柔性尾部的可能相似性。
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