Department of Dermatology, University of California - Davis, Sacramento, CA, U.S.A.
School of Medicine, University of Michigan, Ann Arbor, MI, U.S.A.
Br J Dermatol. 2019 Feb;180(2):289-296. doi: 10.1111/bjd.16918. Epub 2018 Sep 21.
Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side-effects.
To compare the clinical efficacy and side-effect profiles of bakuchiol and retinol in improving common signs of cutaneous facial ageing.
This was a randomized, double-blind, 12-week study in which 44 patients were asked to apply either bakuchiol 0·5% cream twice daily or retinol 0·5% cream daily. A facial photograph and analytical system was used to obtain and analyse high-resolution photographs of patients at 0, 4, 8 and 12 weeks. Patients also completed tolerability assessment questions to review side-effects. During study visits, a board-certified dermatologist, blinded to study group assignments, graded pigmentation and redness.
Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging.
Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promising as a more tolerable alternative to retinol.
补骨脂酚是一种植物化学物质，局部应用时具有皮肤抗衰老作用。早期研究表明，补骨脂酚是局部类视黄醇的功能类似物，因为这两种化合物都能在皮肤中诱导类似的基因表达，并改善皮肤光损伤。尚无体内研究比较这两种化合物的疗效和副作用。
比较补骨脂酚和视黄醇改善常见面部皮肤老化迹象的临床疗效和副作用特征。
这是一项随机、双盲、12 周的研究，共有 44 名患者被要求每天两次涂抹 0.5%补骨脂酚乳膏或每天涂抹 0.5%视黄醇乳膏。使用面部照片和分析系统在 0、4、8 和 12 周时获取和分析患者的高分辨率照片。患者还完成了耐受性评估问题以回顾副作用。在研究访视期间，一位经过董事会认证的皮肤科医生对色素沉着和发红进行盲法评分，不知道研究组的分配。
补骨脂酚和视黄醇均能显著减少皱纹面积和色素沉着，两种化合物之间无统计学差异。视黄醇使用者报告的面部皮肤脱屑和刺痛更多。
我们的研究表明，补骨脂酚在改善光老化方面与视黄醇相当，且耐受性优于视黄醇。补骨脂酚作为一种更耐受的视黄醇替代品具有广阔的前景。
