Department of Vascular Surgery, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Department of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China.
J Cell Mol Med. 2018 Oct;22(10):4568-4587. doi: 10.1111/jcmm.13700. Epub 2018 Jun 29.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at a post-transcriptional level via either the degradation or translational repression of a target mRNA. They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis-related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of miRNAs and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of miRNAs in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between miRNAs and angiogenesis, and miRNA-based biomarkers in the diagnosis, treatment and prognosis of angiogenesis-related diseases, providing an update on the understanding of the clinical value of miRNAs in targeting angiogenesis.
微小 RNA（miRNAs）是一类小的非编码 RNA，通过靶向 mRNA 的降解或翻译抑制，在转录后水平上调节基因表达。它们通过调节与血管生成相关的细胞的增殖、分化、凋亡、迁移和管形成，在血管生成中发挥着不可替代的作用，这些细胞对于众多生理和病理过程是必不可少的，特别是对于血管疾病的发生和发展。miRNAs 调节和血管生成之间的失衡可能导致许多疾病，如癌症、心血管疾病、动脉瘤、川崎病、主动脉夹层、静脉血栓形成和糖尿病微血管并发症。因此，探索 miRNAs 在血管生成中的重要作用非常重要，这可能有助于为血管疾病发现新的和有效的治疗策略。本综述重点关注 miRNAs 与血管生成之间的相互作用，以及 miRNA 作为血管生成相关疾病的诊断、治疗和预后的生物标志物，为 miRNA 在靶向血管生成方面的临床价值提供了最新认识。
