Qiu Lu, Xiao Yu, Liu Yao-Qi, Peng Lian-Xin, Liao Wan, Fu Qiang
a College of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
b Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture , Chengdu 610106 , China.
J Asian Nat Prod Res. 2019 May;21(5):419-425. doi: 10.1080/10286020.2018.1488835. Epub 2018 Jul 2.
The EtOH extract of the roots of Platycodon grandiflorum afforded two new triterpene saponins platycoside P (1) and platycoside Q (2). Their structures were elucidated based on spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against LPS-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed inhibitory activity with the inhibition ratios (%) of 38.6 and 44.1 at 50 μM, respectively.
桔梗根的乙醇提取物得到了两种新的三萜皂苷，桔梗皂苷P（1）和桔梗皂苷Q（2）。基于光谱手段和水解产物阐明了它们的结构。对这些化合物在RAW 246.7巨噬细胞中对脂多糖诱导的肿瘤坏死因子-α产生的抑制活性进行了评估。化合物1和2表现出抑制活性，在50μM时抑制率（%）分别为38.6和44.1。
