Guangdong Institute of Gastroenterology, Guangzhou, China.
Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Cell Death Dis. 2018 Jul 3;9(7):751. doi: 10.1038/s41419-018-0771-y.
Long noncoding RNAs (lncRNAs) have been emerging as master regulators of tumor growth and metastasis, but the functions and underlying mechanisms of lncRNAs in colorectal cancer (CRC) still need to be clarified. Here, we found a novel lncRNA u50535, which was greatly overexpressed in CRC tissues and was associated with poor prognosis in CRC patients. Function studies showed that u50535 was an oncogene in CRC both in vitro and in vivo. In mechanism, through RNA sequencing and rescue assay, we found that u50535 activates CCL20 signaling to promote cell proliferation and migration in CRC. Taken together, these findings suggest that u50535 can promote CRC growth and metastasis and may serve as a potential biomarker in CRC.
长链非编码 RNA（lncRNAs）已成为肿瘤生长和转移的主要调控因子，但 lncRNAs 在结直肠癌（CRC）中的功能和潜在机制仍需阐明。在这里，我们发现了一种新型的 lncRNA u50535，它在 CRC 组织中大量过表达，并与 CRC 患者的不良预后相关。功能研究表明，u50535 在体外和体内都是 CRC 的致癌基因。在机制上，通过 RNA 测序和挽救实验，我们发现 u50535 通过激活 CCL20 信号通路促进 CRC 细胞的增殖和迁移。综上所述，这些发现表明 u50535 可以促进 CRC 的生长和转移，可能成为 CRC 的潜在生物标志物。
