Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Headington, Oxford, United Kingdom.
JAMA Neurol. 2018 Oct 1;75(10):1225-1233. doi: 10.1001/jamaneurol.2018.1603.
Risk of major stroke is high during the hours and days after transient ischemic attack (TIA) and minor stroke but is substantially reduced by urgent medical treatment. Public education campaigns have improved the response after major stroke, but their association with behavior after TIA and minor stroke is uncertain. The number of potentially preventable early recurrent strokes in patients who delay or fail to seek medical attention is unknown.
To investigate the association of public education with delays and failure in seeking medical attention after TIA and minor stroke.
DESIGN, SETTING, AND PARTICIPANTS: Prospective population-based study of all patients with TIA or stroke who sought medical attention between April 1, 2002, and March 31, 2014, registered at 9 general practices in Oxfordshire, United Kingdom. Data analysis took place from July 1, 2013, to March 2, 2015.
Face, Arm, Speech, Time (FAST) public education campaign in the United Kingdom.
Number of early recurrent strokes in patients who delayed or failed to seek medical attention, as well as the odds of seeking urgent attention after TIA and minor stroke before vs after initiation of the public education campaign.
Among 2243 consecutive patients with first TIA or stroke (mean [SD] age, 73.6 [13.4] years; 1126 [50.2%] female; 96.3% of white race/ethnicity), 1656 (73.8%) had a minor stroke or TIA. After the FAST campaign, patients with major stroke more often sought medical attention within 3 hours (odds ratio [OR], 2.56; 95% CI, 1.11-5.90; P = .03). For TIA and minor stroke, there was no improvement in use of emergency medical services (OR, 0.79; 95% CI, 0.50-1.23; P for interaction = .03 vs major stroke) or time to first seeking medical attention within 24 hours (OR, 0.75; 95% CI, 0.48-1.19; P for interaction = .006 vs major stroke). Patient perception of symptoms after TIA and minor stroke was associated with more urgent behavior, but correct perception declined after the FAST campaign (from 37.3% [289 of 774] to 27.6% [178 of 645]; OR, 0.64; 95% CI, 0.51-0.80; P < .001). One hundred eighty-eight patients had a stroke within 90 days of their initial TIA or stroke, of whom 93 (49.5%) followed unheeded TIAs for which no medical attention was sought, similar before and after the FAST campaign (43 of 538 [8.0%] before vs 50 of 615 [8.1%] after, P = .93).
This study suggests that in contrast to major stroke, extensive FAST-based public education has not improved the response to TIA and minor stroke in the United Kingdom, emphasizing the need for campaigns that are tailored to transient and less severe symptoms.
短暂性脑缺血发作(TIA)和小中风后数小时和数天内发生大中风的风险很高,但紧急医疗治疗可显著降低这种风险。公众教育活动提高了大中风后的反应,但它们与 TIA 和小中风后的行为之间的关系尚不确定。不知道在那些延迟或未能寻求医疗关注的患者中,有多少早期复发性中风是可以预防的。
研究公众教育与 TIA 和小中风后延迟和未能寻求医疗关注之间的关联。
设计、地点和参与者:这是一项在英国牛津郡的 9 家普通诊所注册的所有 TIA 或中风患者的前瞻性基于人群的研究。数据分析于 2013 年 7 月 1 日至 2015 年 3 月 2 日进行。
英国的 FAST 公众教育活动,包括识别中风的面部、手臂、言语、时间(FAST)症状。
延迟或未能寻求医疗关注的患者中早期复发性中风的数量,以及 TIA 和小中风后寻求紧急关注的可能性,与 FAST 公众教育活动开始前和开始后相比。
在 2243 名连续的首次 TIA 或中风患者(平均[标准差]年龄,73.6[13.4]岁;1126[50.2%]女性;96.3%为白种人/种族)中,1656 名(73.8%)患有小中风或 TIA。在 FAST 运动之后,患有大中风的患者更常在 3 小时内寻求医疗关注(优势比[OR],2.56;95%置信区间[CI],1.11-5.90;P = .03)。对于 TIA 和小中风,紧急医疗服务的使用没有改善(OR,0.79;95%CI,0.50-1.23;P 交互 = .03 与大中风相比)或在 24 小时内首次寻求医疗关注的时间(OR,0.75;95%CI,0.48-1.19;P 交互 = .006 与大中风相比)。TIA 和小中风后患者对症状的感知与更紧急的行为相关,但正确的感知在 FAST 运动后下降(从 37.3%(289/774)降至 27.6%(178/645);OR,0.64;95%CI,0.51-0.80;P < .001)。188 名患者在最初的 TIA 或中风后 90 天内发生中风,其中 93 名(49.5%)未听从未寻求医疗关注的 TIA,这与 FAST 运动前后相似(538 例中的 43 例[8.0%],615 例中的 50 例[8.1%],P = .93)。
这项研究表明,与大中风相比,广泛的基于 FAST 的公众教育并没有改善英国对 TIA 和小中风的反应,强调需要针对短暂和较轻的症状开展量身定制的宣传活动。