Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Departments of Surgery-General Surgery and Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA; Department of Surgery, VA Nebraska-Western Iowa Health Care System, Omaha, NE, 68105, USA.
Biomaterials. 2018 Oct;179:46-59. doi: 10.1016/j.biomaterials.2018.06.031. Epub 2018 Jun 22.
Uncontrolled hemorrhage, which typically involves the torso and/or limb junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix ("peanut") fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re-expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples. These nanofiber peanuts are capable of being packed into a syringe for injection. Further in vivo tests indicated the effectiveness of nanofiber peanuts for hemostasis in a porcine liver injury model. This new class of nanofiber-based materials may hold great promise for hemostatic applications.
在院前环境中，无法控制的出血（通常涉及躯干和/或肢体交界处）仍然是一个巨大的挑战。在这里，我们首次报告了一种可注射的超弹性纳米纤维矩形基质（“花生”），它是通过静电纺丝、气体发泡、水凝胶涂层和交联技术的组合制造的。压缩的纳米纤维花生能够在 10 秒内在大气、水和血液中重新扩张到原来的形状。与目前的商业产品相比，这种纳米纤维花生具有更大的吸水/血能力和更高的全血凝血试验效果，特别是对于固定有凝血酶的样品。这些纳米纤维花生可以包装到注射器中进行注射。进一步的体内试验表明，纳米纤维花生在猪肝损伤模型中的止血效果良好。这种新型纳米纤维材料可能在止血应用方面具有巨大的潜力。
