Sharifi-Rad Javad, Tayeboon Ghazaleh S, Niknam Fereshteh, Sharifi-Rad Majid, Mohajeri Maryam, Salehi Bahare, Iriti Marcello, Sharifi-Rad Mehdi
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Biology, Payamenoor University, PO BOX19395-3697, Tehran, Iran.
Cell Mol Biol (Noisy-le-grand). 2018 Jun 25;64(8):50-56.
Veronica persica (Persian speedwell) is a flowering plant local to Eurasia. In this study, several analyses were done to discover the antimicrobial and scolicidal activities and acetyl cholinesterase (AChE), tyrosinase (TYR), lipoxygenase (LOX), and xanthine oxidase (XO) inhibitory activities of V. persica extract. The results presented that B. subtilis was the most susceptible to the extract (MIC = 40.3 μg/mL), while P. aeruginosa was the most resistant strain (MIC = 250.9 μg/mL) among all bacteria evaluated. The extracts demonstrated significant activity versus E. granulosus (P < 0.5) with dose-dependent inhibitions of the protoscolices. The analyzed plant extract exhibited a high AChE and TYR inhibitory activity 55.3% and 52.7% (at the highest utilized dose - 3 mg/mL), respectively. The extract also showed high anti-inflammatory activities in analyses tested. Our research proposed that extract of this plant could be promising to the human health, markedly in the infectious, neurodegenerative and inflammatory disorders.
波斯婆婆纳是一种原产于欧亚大陆的开花植物。在本研究中，进行了多项分析，以探究波斯婆婆纳提取物的抗菌、杀绦虫活性以及对乙酰胆碱酯酶（AChE）、酪氨酸酶（TYR）、脂氧合酶（LOX）和黄嘌呤氧化酶（XO）的抑制活性。结果表明，在所有评估的细菌中，枯草芽孢杆菌对该提取物最为敏感（最低抑菌浓度[MIC]=40.3μg/mL），而铜绿假单胞菌是最具抗性的菌株（MIC=250.9μg/mL）。提取物对细粒棘球绦虫显示出显著活性（P<0.5），对原头蚴具有剂量依赖性抑制作用。所分析的植物提取物表现出较高的乙酰胆碱酯酶和酪氨酸酶抑制活性，分别为55.3%和52.7%（在最高使用剂量3mg/mL时）。在测试分析中，该提取物还显示出较高的抗炎活性。我们的研究表明，这种植物的提取物对人类健康可能具有前景，尤其在感染性、神经退行性和炎症性疾病方面。
