Živković Jelena Č, Barreira João C M, Šavikin Katarina P, Alimpić Ana Z, Stojković Dejan S, Dias Maria Inês, Santos-Buelga Celestino, Duletić-Laušević Sonja N, Ferreira Isabel C F R
Institute for Medicinal Plants Research "Dr. Josif Pančić", Tadeuša Košćuška 1, RS-11000, Belgrade, Serbia.
CIMO/Escola Superior Agrária, Instituto Politécnico de Bragança, Apartado 1172, PT-5301-855, Bragança.
Chem Biodivers. 2017 Aug;14(8). doi: 10.1002/cbdv.201700167. Epub 2017 Jul 7.
Neuroprotective potential of V. teucrium and V. jacquinii methanol extracts was analyzed. Chemical analysis of investigated extracts showed the presence of phenolic acid derivatives, flavonoids and one secoiridoid. The detected flavonoids derived from flavones (luteolin and isoscutellarein in V. jacquinii; apigenin, isoscutellarein and luteolin in V. teucrium) and flavonol (quercetin in V. jacquinii). Acteoside was the dominant compound in V. jacquinii, while plantamajoside and isoscutellarein 7-O-(6‴-O-acetyl)-β-allosyl (1‴→2‴)-β-glucoside were the major phenolics in V. teucrium. Additionally, the antineurodegenerative activity was tested at concentrations of 25, 50, and 100 μg/ml using acetylcholinesterase (AChE) and tyrosinase (TYR) assays. The inhibition of both enzymes was achieved with the investigated extracts, ranging from 22.78 to 35.40% for AChE and from 9.57 to 16.38% for TYR. There was no statistical difference between the activities of the analyzed extracts. Our data indicate that V. teucrium and V. jacquinii may have beneficial effects against Alzheimer's and Parkinson's disease.
分析了香科科属植物毛果香科科和雅克香科科甲醇提取物的神经保护潜力。对所研究提取物的化学分析表明，其含有酚酸衍生物、黄酮类化合物和一种裂环烯醚萜。检测到的黄酮类化合物来源于黄酮（雅克香科科中的木犀草素和异野黄芩素；毛果香科科中的芹菜素、异野黄芩素和木犀草素）和黄酮醇（雅克香科科中的槲皮素）。紫叶假人参苷是雅克香科科中的主要化合物，而大车前苷和异野黄芩素7 - O -（6''' - O - 乙酰基）-β - 阿洛糖基（1'''→2'''）-β - 葡萄糖苷是毛果香科科中的主要酚类物质。此外，使用乙酰胆碱酯酶（AChE）和酪氨酸酶（TYR）测定法，在25、50和100μg/ml的浓度下测试了抗神经退行性活性。所研究的提取物对这两种酶均有抑制作用，AChE的抑制率为22.78%至35.40%，TYR的抑制率为9.57%至16.38%。分析的提取物活性之间没有统计学差异。我们的数据表明，毛果香科科和雅克香科科可能对阿尔茨海默病和帕金森病有有益作用。
