Bristol J B, Emmett P M, Heaton K W, Williamson R C
Br Med J (Clin Res Ed). 1985 Nov 23;291(6507):1467-70. doi: 10.1136/bmj.291.6507.1467.
The habitual diet of 50 patients with large bowel cancer, as assessed by a dietary history method, was compared with that of 50 closely matched controls. Patients were included only if their symptoms were unlikely to have changed previous eating habits. The mean daily intakes of all major nutrient classes and of dietary fibre were estimated. Patients with large bowel cancer consumed 16% more energy than controls (mean (SEM) daily intake 9.92 (0.41) v 8.56 (0.32) MJ (2370 (98) v 2046 (76) kcal), respectively; p less than 0.0001), mainly in the form of carbohydrate (21% more; 282.6 (13.7) v 233.4 (10.5) g; p less than 0.0001) and fat (14% more; 100.8 (4.3) v 88.4 (3.2) g; p less than 0.001). The extra carbohydrate was largely in the form of sugars depleted in fibre and the extra fat as combinations of fat and such sugars. As the selection criteria used make it unlikely that this eating pattern was caused by the disease the data suggest that a high intake of sugars depleted in fibre and fat predisposes to the development of large bowel cancer.
通过饮食史方法评估了50例大肠癌患者的习惯饮食，并与50例年龄、性别相匹配的对照者的习惯饮食进行了比较。仅当患者的症状不太可能改变其既往饮食习惯时才纳入研究。估算了所有主要营养素类别和膳食纤维的每日平均摄入量。大肠癌患者的能量摄入量比对照组高16%（平均（标准误）每日摄入量分别为9.92（0.41）MJ对8.56（0.32）MJ，即2370（98）kcal对2046（76）kcal；p<0.0001），主要以碳水化合物（高21%；282.6（13.7）g对233.4（10.5）g；p<0.0001）和脂肪（高14%；100.8（4.3）g对88.4（3.2）g；p<0.001）的形式摄入。额外摄入的碳水化合物主要是膳食纤维含量低的糖类，额外摄入的脂肪则是脂肪与这类糖类的混合物。由于所采用的选择标准使得这种饮食模式不太可能由疾病引起，因此数据表明，高纤维含量低的糖类和脂肪的摄入易引发大肠癌。
