Abot Anne, Cani Patrice D, Knauf Claude
NeuroMicrobiota, European Associated Laboratory (EAL), INSERM, Université catholique de Louvain (UCL), Toulouse, France.
INSERM U1220 Institut de Recherche en Santé Digestive (IRSD), CHU Purpan, Université Toulouse III Paul Sabatier, Paris, France.
Front Endocrinol (Lausanne). 2018 Jun 22;9:328. doi: 10.3389/fendo.2018.00328. eCollection 2018.
The gut is one of the most important sources of bioactive peptides in the body. In addition to their direct actions in the brain and/or peripheral tissues, the intestinal peptides can also have an impact on enteric nervous neurons. By modifying the endogenousproduction of these peptides, one may expect modify the "local" physiology such as glucose absorption, but also could have a "global" action the gut-brain axis. Due to the various origins of gut peptides (i.e., nutrients, intestinal wall, gut microbiota) and the heterogeneity of enteric neurons population, the potential physiological parameters control by the interaction between the two partners are multiple. In this review, we will exclusively focus on the role of enteric nervous system as a potential target of gut peptides to control glucose metabolism and food intake. Potential therapeutic strategies based on administration of gut peptides to treat type 2 diabetes will be described.
肠道是体内生物活性肽最重要的来源之一。除了它们在大脑和/或外周组织中的直接作用外，肠道肽还可对肠神经神经元产生影响。通过改变这些肽的内源性产生，人们不仅可以预期改变“局部”生理功能，如葡萄糖吸收，还可能对肠-脑轴产生“全局”作用。由于肠道肽的来源多样（即营养素、肠壁、肠道微生物群）以及肠神经元群体的异质性，这两者相互作用所控制的潜在生理参数众多。在本综述中，我们将专门关注肠神经系统作为肠道肽控制葡萄糖代谢和食物摄入的潜在靶点的作用。还将描述基于给予肠道肽治疗2型糖尿病的潜在治疗策略。
