Anbazhagan Sathiyaseelan, Thangavelu Kalaichelvan Puthupalayam
Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.
Alka Research Foundation, Maruthamalai Adivaaram, Coimbatore, Tamil Nadu, India.
J Adv Res. 2018 May 14;14:63-71. doi: 10.1016/j.jare.2018.05.005. eCollection 2018 Nov.
Chitosan composite material has been used as an efficient drug carrier for potential drug delivery systems in specific cases of wound dressing management. In the present study, 0.5 g/L of the antibiotic tetracycline hydrochloride (TCH) was loaded into 1% fungal chitosan (FCS) incorporated with 0.2% of extract (AVE). Two types of sponges were prepared, with and without AVE, such as FCS-AVE-TCH and FCS-TCH, respectively. They were characterized by UV-Visible spectrophotometer, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and scanning electron microscopy (SEM). A constant amount of cumulative TCH release was observed from FCS-AVE-TCH composite sponges at the phosphate buffer saline (pH 7.4), they exhibited good antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, the Vero cells (African green monkey kidney cell line) treated by the composites showed augmented cell viability, which suggests that it could be used as a cost-effective, potential wound dressing material.
壳聚糖复合材料已被用作一种高效的药物载体，用于伤口敷料管理特定情况下的潜在药物递送系统。在本研究中，将0.5 g/L的抗生素盐酸四环素（TCH）负载到含有0.2%提取物（AVE）的1%真菌壳聚糖（FCS）中。制备了两种类型的海绵，分别含AVE和不含AVE，即FCS-AVE-TCH和FCS-TCH。通过紫外可见分光光度计、衰减全反射傅里叶变换红外光谱（ATR-FTIR）和扫描电子显微镜（SEM）对它们进行了表征。在磷酸盐缓冲盐水（pH 7.4）中，从FCS-AVE-TCH复合海绵中观察到TCH的累积释放量恒定，它们对革兰氏阳性菌和革兰氏阴性菌均表现出良好的抗菌活性。此外，用复合材料处理的Vero细胞（非洲绿猴肾细胞系）显示细胞活力增强，这表明它可以用作一种经济高效的潜在伤口敷料材料。
