Wen Yanyi, Yu Bing, Zhu Zhongjie, Yang Zhuoran, Shao Wei
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Polymers (Basel). 2020 Aug 26;12(9):1926. doi: 10.3390/polym12091926.
In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.
在本研究中，制备了将抗生素盐酸四环素（TCH）负载到与明胶（G/SA）混合的藻酸盐中的海绵。通过扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）和热重（TG）分析对G/SA海绵进行了表征。G/SA海绵呈现出具有高孔隙率的三维网络结构。观察到G/SA海绵具有优异的溶胀行为和可控性的TCH释放性能。此外，它们对革兰氏阳性菌和革兰氏阴性菌均表现出良好的抗菌活性。
