Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Comunidad Valenciana, Spain.
Molecular Pathology Unit, Department of Pathology, La Fe University Hospital, University of Valencia, Valencia, Comunidad Valenciana, Spain.
Head Face Med. 2018 Jul 13;14(1):10. doi: 10.1186/s13005-018-0167-3.
The role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied. The objective is to describe the clinicopathological findings in a series of OOCs from a Spanish population that were investigated in relation to the possible presence of HPV.
A clinicopathological retrospective analysis followed by a molecular analysis of 28 high- and low-risk HPV genotypes was performed in OOC samples of patients seen during the last 15-years in a Spanish tertiary care center.
Of 115 odontogenic cysts with keratinization, 16 cases of OOCs were confirmed and evaluated. OOCs occurred predominantly in the mandible of males (mean age 36.06 ± 13.16 years). Swelling of the jaw followed by pain were the most common clinical symptoms, and 56.5% of the OOC cases were associated with an unerupted tooth. After a mean post-cystectomy follow-up of 3.8 years, only one recurrent case was observed, resulting in a verrucous cystic lesion that was considered premalignant after immunohistological examination. DNA extraction was successful from 14 of the 16 OOC cases. None of the primary OCCs or the single recurrent OOC were positive for HPV in the molecular analysis.
OOCs show a very limited potential for recurrence. Our results suggest that neither high- or low-risk HPV subtypes are likely to play a role in the etiology or neoplastic transformation of OOC, at least in the Spanish population.
人乳头瘤病毒（HPV）在正角化牙源性角化囊肿（OOC）中的作用鲜有研究。本研究旨在描述来自西班牙人群的一系列 OOC 的临床病理发现，并对其进行 HPV 可能存在的研究。
对西班牙一家三级护理中心过去 15 年就诊的患者的 OOC 样本进行了临床病理回顾性分析，并对 28 种高危和低危 HPV 基因型进行了分子分析。
在 115 例有角化的牙源性囊肿中，确认并评估了 16 例 OOC。OOC 主要发生在男性的下颌骨（平均年龄 36.06±13.16 岁）。颌骨肿胀后疼痛是最常见的临床症状，56.5%的 OOC 与未萌出牙有关。在囊肿切除后平均随访 3.8 年后，仅观察到 1 例复发病例，导致免疫组织化学检查后被认为是癌前病变的疣状囊性病变。16 例 OOC 中有 14 例成功提取了 DNA。在分子分析中，原发性 OOC 或唯一的复发性 OOC 均未检测到 HPV。
OOC 具有非常有限的复发潜能。我们的研究结果表明，高危或低危 HPV 亚型不太可能在 OOC 的病因或肿瘤转化中发挥作用，至少在西班牙人群中如此。
