来自软珊瑚共生真菌 Simplicillium sp. SCSIO41209 的肽。
Peptides from the Soft Coral-associated Fungus Simplicillium sp. SCSIO41209.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, 510301, Guangzhou, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
School of Life Sciences and Biomedical Center, Sun Yat-sen University, Guangzhou, 510275, China.
出版信息
Phytochemistry. 2018 Oct;154:56-62. doi: 10.1016/j.phytochem.2018.06.014. Epub 2018 Jul 3.
Five new peptides, Sinulariapeptides A-E together with seven known peptides (6-12) were isolated from the soft coral associated fungus Simplicillium sp. SCSIO 41209. The structures of the new compounds and their absolute configurations were established on the basis of spectroscopic analysis including NMR, MS and ECD. All the Compounds (except sinulariapeptides B-D) were tested for the inhibitory activities of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), and antifungal activities against five plant pathogenic fungi. Simplicilliumtides B and cyclo(L-Val-L-Pro) showed inhibitory activity with the IC values of 35.0 and 25.9 μM, sinulariapeptides A, simplicilliumtides J, verlamelins A and B exhibited potent inhibition against Colletotrichum asianum with the MIC values of range from 4.9 to 9.8 μg/mL and simplicilliumtides J, verlamelins A and B displayed inhibition against Pyricularia oryza Cav with the MIC values in the range of 19.5-78.1 μg/ml, respectively.
从与软珊瑚共生的真菌 Simplicillium sp. SCSIO 41209 中分离得到了五个新的肽，即 Sinulariapeptides A-E，以及七个已知的肽（6-12）。新化合物的结构及其绝对构型是基于包括 NMR、MS 和 ECD 在内的光谱分析确定的。所有化合物（除了 sinulariapeptides B-D）都测试了对结核分枝杆菌蛋白酪氨酸磷酸酶 B（MptpB）的抑制活性以及对五种植物病原真菌的抗真菌活性。Simplicilliumtides B 和环（L-Val-L-Pro）显示出抑制活性，IC 值分别为 35.0 和 25.9 μM，sinulariapeptides A、simplicilliumtides J、verlamelins A 和 B 对炭疽病菌表现出很强的抑制作用，MIC 值范围为 4.9 到 9.8 μg/mL，simplicilliumtides J、verlamelins A 和 B 对稻瘟病菌的抑制作用，MIC 值分别在 19.5-78.1 μg/ml 范围内。
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