一种在近交系小鼠品系中常见的内源性小鼠乳腺肿瘤病毒基因组位于6号染色体上。
An endogenous mouse mammary tumor virus genome common in inbred mouse strains is located on chromosome 6.
作者信息
Robbins J M, Gallahan D, Hogg E, Kozak C, Callahan R
出版信息
J Virol. 1986 Feb;57(2):709-13. doi: 10.1128/JVI.57.2.709-713.1986.
We have examined EcoRI-restricted cellular DNA from mouse-hamster somatic cell hybrids. Results of this analysis show that the unit II mouse mammary tumor virus proviral genome is located on mouse chromosome 6. Restriction analysis of cellular DNA from (C3H/OuJ X Czech II) X Czech II backcross mice showed a strong linkage between unit II and Igk. The gene order of these markers on chromosome 6 relative to the Raf and Kirsten murine sarcoma virus ras-2 proto-oncogenes was established.
我们检测了来自小鼠-仓鼠体细胞杂种的经EcoRI酶切的细胞DNA。该分析结果表明，II型小鼠乳腺肿瘤病毒前病毒基因组位于小鼠6号染色体上。对（C3H/OuJ×捷克II）×捷克II回交小鼠的细胞DNA进行的限制性分析显示，II型与Igk之间存在强连锁。确定了这些标记在6号染色体上相对于Raf和 Kirsten 鼠肉瘤病毒ras-2原癌基因的基因顺序。
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