Wallach H W
Arch Intern Med. 1977 Apr;137(4):532-5.
Two patients with locally advanced carcinoma of the breast had radiation therapy as primary treatment. Within one year, a lupus-like syndrome developed characterized by pneumonitis, pleural effusion, and positive fluorescent antinuclear antibody (FANA) reaction and lupus erythematosus (LE) preparation. Pericarditis developed in one patient and leukopenia in the other. The bilateral pulmonary disease, serological abnormalities, and rapid and sustained response to administration of prednisone made the diagnosis of systemic lupus erythematosus more likely than radiation-induced disease or metastic carcinoma. Radiation to normal and/or malignant tissue may have initiated an immunological response leading to a lupus-like syndrome.
两名局部晚期乳腺癌患者接受放射治疗作为主要治疗手段。在一年内，出现了类似狼疮的综合征，其特征为肺炎、胸腔积液、荧光抗核抗体（FANA）反应阳性以及红斑狼疮（LE）细胞检查阳性。其中一名患者发生了心包炎，另一名患者出现了白细胞减少。双侧肺部疾病、血清学异常以及对泼尼松给药的快速且持续反应，使得系统性红斑狼疮的诊断比放射性疾病或转移性癌更有可能。对正常和/或恶性组织的辐射可能引发了免疫反应，导致类似狼疮的综合征。
