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肌肉稳态、萎缩和消瘦的分子见解

Molecular Insights into Muscle Homeostasis, Atrophy and Wasting.

作者信息

Scicchitano Bianca Maria, Dobrowolny Gabriella, Sica Gigliola, Musarò Antonio

机构信息

Istituto di Istologia e Embriologia, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Largo Francesco Vito 1-00168, Roma, Italy.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.

出版信息

Curr Genomics. 2018 Aug;19(5):356-369. doi: 10.2174/1389202919666180101153911.

DOI:10.2174/1389202919666180101153911
PMID:30065611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6030854/
Abstract

Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.

摘要

肌肉稳态由细胞蛋白质合成与降解之间的微妙平衡来保证，其改变会导致肌肉萎缩和疾病。在本综述中，我们描述了参与肌肉生长和稳态的主要合成代谢途径以及在肌肉病变中过度激活的蛋白水解系统。对这些途径的调节是药物干预的一个有吸引力的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/80f2f1c6338d/CG-19-356_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/1b2b56b46d5f/CG-19-356_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/aab895baab87/CG-19-356_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/8e36b5c8a743/CG-19-356_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/c15f77324875/CG-19-356_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/80f2f1c6338d/CG-19-356_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/1b2b56b46d5f/CG-19-356_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/aab895baab87/CG-19-356_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/8e36b5c8a743/CG-19-356_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/c15f77324875/CG-19-356_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0b6/6030854/80f2f1c6338d/CG-19-356_F5.jpg

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