衰老的免疫学研究。III. 老年人淋巴细胞对植物凝集素反应受损的细胞动力学基础。
Immunological studies of Aging. III. Cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins.
作者信息
Inkeles B, Innes J B, Kuntz M M, Kadish A S, Weksler M E
出版信息
J Exp Med. 1977 May 1;145(5):1176-87. doi: 10.1084/jem.145.5.1176.
Abstract
The basis for the age-associated defect in the response of lymphocytes to plant lectins has been studied. Using three independent assays we have shown that the number of mitogen-responsive cells is markedly reduced in lymphocyte preparations from old persons. In addition, studies using colchicine bloock and thymidine pulse techniques have revealed a failure of mitogen-responsive cells from old persons to expand into a proliferating pool of lymphocytes as is observed when lymphocytes from young persons are cultured with phytohemagglutinin. Thus, the impaired response of lymphocytes from old persons to mitogens is attributable to a reduced number of mitogen responsive cells and their failure to undergo clonal expansion.
摘要
对淋巴细胞对植物凝集素反应中与年龄相关缺陷的基础进行了研究。通过三项独立检测，我们发现老年人淋巴细胞制剂中有丝分裂原反应性细胞的数量显著减少。此外，使用秋水仙碱阻断和胸腺嘧啶核苷脉冲技术的研究表明，与年轻人的淋巴细胞用植物血凝素培养时所观察到的情况不同，老年人的有丝分裂原反应性细胞无法扩展为增殖性淋巴细胞池。因此，老年人淋巴细胞对有丝分裂原的反应受损是由于有丝分裂原反应性细胞数量减少及其无法进行克隆扩增。
相似文献
1
Immunological studies of Aging. III. Cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins.衰老的免疫学研究。III. 老年人淋巴细胞对植物凝集素反应受损的细胞动力学基础。
J Exp Med. 1977 May 1;145(5):1176-87. doi: 10.1084/jem.145.5.1176.
2
Ultrastructural features of phytohemagglutinin and concanavalin A-responsive lymphocytes in chronic lymphocytic leukemia.慢性淋巴细胞白血病中对植物血凝素和伴刀豆球蛋白A反应性淋巴细胞的超微结构特征
Acta Haematol. 1973;50(3):129-42. doi: 10.1159/000208340.
3
Augmentation of the response to mitogens in cultures containing different syngeneic lymphoid cells.
Boll Ist Sieroter Milan. 1974;53(1):suppl:182.
4
Cellular interactions in the proliferative response of human T and B lymphocytes to phytomitogens and allogeneic lymphocytes.人类T淋巴细胞和B淋巴细胞对植物有丝分裂原及同种异体淋巴细胞增殖反应中的细胞间相互作用
J Exp Med. 1974 Jun 1;139(6):1553-67. doi: 10.1084/jem.139.6.1553.
5
6
T mitogens trigger LPS responsiveness in mouse thymus cells.T 有丝分裂原可触发小鼠胸腺细胞中的脂多糖反应性。
J Immunol. 1975 Mar;114(3):1004-7.
7
Synergy between human T and B lymphocytes in their response to phythaemagglutinin and pokeweed mitogen.人T淋巴细胞和B淋巴细胞在对植物血凝素和商陆有丝分裂原反应中的协同作用。
Immunology. 1976 Aug;31(2):273-81.
8
Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations.淋巴细胞激活。V. 使用特定的T细胞和B细胞群体对有丝分裂原的增殖反应进行定量分析。
Clin Exp Immunol. 1973 Aug;14(4):581-96.
9
Impaired lymphocyte function in aged humans.老年人淋巴细胞功能受损。
J Clin Invest. 1974 Jan;53(1):99-104. doi: 10.1172/JCI107565.
10
Blastogenic response of Toxoplasma-infected mouse spleen cells to T- and B-cell mitogens.弓形虫感染小鼠脾细胞对T细胞和B细胞有丝分裂原的增殖反应。
Clin Exp Immunol. 1975 Oct;22(1):167-76.
引用本文的文献
1
Identification of prognostic aging-related genes associated with immunosuppression and inflammation in head and neck squamous cell carcinoma.鉴定与头颈部鳞状细胞癌免疫抑制和炎症相关的预后相关基因。
Aging (Albany NY). 2020 Nov 24;12(24):25778-25804. doi: 10.18632/aging.104199.
2
The human immunosenescence phenotype: does it exist?人类免疫衰老表型：它存在吗？
Semin Immunopathol. 2020 Oct;42(5):537-544. doi: 10.1007/s00281-020-00810-3. Epub 2020 Aug 5.
3
Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model.将奥卡姆剃刀原理应用于胰腺炎预后评估：一个四变量预测模型。
Ann Surg. 2006 Mar;243(3):380-8. doi: 10.1097/01.sla.0000202213.22389.36.
4
Immunodeficiency of aging.衰老的免疫缺陷
Drugs Aging. 1997 Nov;11(5):374-97. doi: 10.2165/00002512-199711050-00005.
5
Cytokine production pathway in the elderly.老年人细胞因子产生途径
Immunol Res. 1996;15(1):84-90. doi: 10.1007/BF02918286.
6
7
Reduced lymphocyte colony formation with age.淋巴细胞集落形成随年龄增长而减少。
Clin Exp Immunol. 1982 Jul;49(1):129-34.
8
Age-related effects on the number of human lymphocytes in culture initially responding to an antigenic stimulus.年龄对培养中最初对抗抗原刺激的人类淋巴细胞数量的影响。
Clin Exp Immunol. 1982 Jan;47(1):138-46.
9
Immunological responses of healthy elderly population.健康老年人群的免疫反应。
Clin Exp Immunol. 1982 May;48(2):403-10.
10
Antibody-specific immunoregulation and the immunodeficiency of aging.抗体特异性免疫调节与衰老免疫缺陷
J Exp Med. 1981 Aug 1;154(2):547-51. doi: 10.1084/jem.154.2.547.
本文引用的文献
1
Mitogenic effect of phytohaemagglutinin at different ages.不同年龄段植物血凝素的促有丝分裂作用。
Nature. 1967 Jul 8;215(5097):193-4. doi: 10.1038/215193a0.
2
An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
Transplantation. 1968 Sep;6(6):761-4. doi: 10.1097/00007890-196809000-00002.
3
Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.组织相容性匹配。VI. 混合淋巴细胞培养试验的小型化：初步报告。
Transplantation. 1971 Mar;11(3):268-73. doi: 10.1097/00007890-197103000-00005.
4
Cytochemical identification of monocytes and granulocytes.单核细胞和粒细胞的细胞化学鉴定。
Am J Clin Pathol. 1971 Mar;55(3):283-90. doi: 10.1093/ajcp/55.3.283.
5
Impaired lymphocyte function in aged humans.老年人淋巴细胞功能受损。
J Clin Invest. 1974 Jan;53(1):99-104. doi: 10.1172/JCI107565.
6
Stimulated lymphocyte cultures: responder recruitment and cell cycle kinetics.刺激淋巴细胞培养：应答细胞招募与细胞周期动力学
J Exp Med. 1974 May 1;139(5):1037-48. doi: 10.1084/jem.139.5.1037.
7
Rosette-forming T cells in human peripheral blood at different ages.
Cell Immunol. 1974 May;12(2):323-5. doi: 10.1016/0008-8749(74)90085-9.
8
The sheep-cell rosette: test on human peripheral blood lymyphocytes: an analysis of some analysis of some variable factors in the technique.绵羊细胞玫瑰花结试验：对人外周血淋巴细胞的检测：该技术中一些可变因素的分析
Br J Haematol. 1974 Oct;28(2):245-51. doi: 10.1111/j.1365-2141.1974.tb06659.x.
9
Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.胸腺产物的研究。IV. 成年NZB和（NZB×NZW）F1小鼠血清中不存在“胸腺活性”
Clin Exp Immunol. 1973 Jun;14(2):247-56.
10
Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.年轻和年长受试者外周血淋巴细胞的植物促细胞分裂剂反应
Clin Exp Immunol. 1974 Aug;17(4):657-64.
Zotero 插件