克罗恩病患者的无血浆氨基酸谱：与克罗恩病活动指数的关系
Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index.
作者信息
Chiba Toshimi, Suzuki Kazuyuki, Matsumoto Takayuki
机构信息
Division of Internal Medicine, Department of Oral Medicine, School of Dentistry, Iwate Medical University, Morioka, Japan.
Department of Nutritional Sciences, Faculty of Nutritional Sciences, Morioka University, Takizawa, Japan.
出版信息
Clin Med Insights Gastroenterol. 2018 Jul 30;11:1179552218791173. doi: 10.1177/1179552218791173. eCollection 2018.
UNLABELLED
We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn's disease (CD) activity index (CDAI) in patients with CD.
METHODS
We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity.
RESULTS
In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA.
CONCLUSIONS
In patients with CD, plasma amino acids appear to be associated with disease activity.
未标注
我们旨在阐明克罗恩病（CD）患者血浆游离氨基酸（PFAA）谱与CD活动指数（CDAI）之间的关系。
方法
我们测量了29例CD患者的空腹PFAA浓度及其与疾病活动的相关性。
结果
在所有患者中，CDAI与缬氨酸、蛋氨酸、亮氨酸、组氨酸、色氨酸、丙氨酸、酪氨酸、总氨基酸（TAA）、非必需氨基酸（NEAA）、必需氨基酸（EAA）和支链氨基酸（BCAA）的浓度之间存在显著相关性。在回结肠型CD患者中，CDAI与缬氨酸、组氨酸、色氨酸、谷氨酰胺、TAA、NEAA、EAA和BCAA之间存在显著相关性。在回肠型中，CDAI与苏氨酸、缬氨酸、组氨酸、丝氨酸和甘氨酸之间存在显著相关性。在结肠型中，CDAI与缬氨酸、组氨酸、色氨酸、TAA、NEAA、EAA和BCAA之间存在显著相关性。
结论
在CD患者中，血浆氨基酸似乎与疾病活动有关。
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