Bacon L D, Ch'ng L K, Spencer J, Benedict A A, Fadly A M, Witter R L, Crittenden L B
Immunogenetics. 1986;23(4):213-20. doi: 10.1007/BF00373015.
Chickens from Regional Poultry Research Laboratory (RPRL) inbred line 6(3) are resistant to virally-induced Marek's disease (MD) and lymphoid leukosis (LL) and are relatively strong regressors of virally-induced Rous sarcomas. In contrast, RPRL line 100 chickens are highly susceptible to MD and LL and are weaker regressors of Rous sarcomas than line 6(3). RPRL lines 100 and 6(3) differ for alleles at the IgG-1 (G-1) allotype locus, but have identical IgM-1 (M-1) allotype alleles. To test the possible association of the G-1 locus with variations in resistance to virally-induced tumors, homozygous and heterozygous genotypes among F3 crosses were infected. F3 chickens with different G-1 types were comparable in their resistance to MD tumors following inoculation with the JM strain of the MD virus, and for their ability to regress Rous sarcoma tumors induced by the Rous sarcoma virus (RSV) RAV-1. However, following RAV-1 virus infection a smaller proportion of G-1a/G-1aF3 or F4 birds developed LL tumors than G-1a/G-1e and G-1e/G-1e birds. Genes determining immunoglobulin heavy chains were therefore associated with a recessive resistance to B-cell lymphomagenesis in chickens.
来自区域家禽研究实验室（RPRL）近交系6(3)的鸡对病毒诱导的马立克氏病（MD）和淋巴细胞白血病（LL）具有抗性，并且是病毒诱导的劳斯肉瘤相对较强的消退者。相比之下，RPRL 100系鸡对MD和LL高度易感，并且在劳斯肉瘤消退方面比6(3)系弱。RPRL 100系和6(3)系在IgG-1（G-1）同种异型位点的等位基因不同，但具有相同的IgM-1（M-1）同种异型等位基因。为了测试G-1位点与对病毒诱导肿瘤抗性变化的可能关联，对F3杂交后代中的纯合子和杂合子基因型进行了感染。接种MD病毒JM株后，不同G-1类型的F3鸡对MD肿瘤的抗性以及对劳斯肉瘤病毒（RSV）RAV-1诱导的劳斯肉瘤肿瘤的消退能力相当。然而，在感染RAV-1病毒后，G-1a/G-1a F3或F4鸡发生LL肿瘤的比例低于G-1a/G-1e和G-1e/G-1e鸡。因此，决定免疫球蛋白重链的基因与鸡对B细胞淋巴瘤发生的隐性抗性相关。
