Xue Jiang-Yang, Huang Chao, Wang Wei, Li Hai-Bo, Sun Ming, Xie Min
Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China.
Central Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China,
Onco Targets Ther. 2018 Jul 27;11:4387-4393. doi: 10.2147/OTT.S166961. eCollection 2018.
Multiple studies have demonstrated that lncRNAs extensively participate in human cancer proliferation and metastasis. Epigenetic modification, transcriptional and posttranscriptional regulatory mechanisms are involved in lncRNA-led tumorigenesis and transfer. Recently, a novel identified homeobox (HOX) A11 antisense lncRNA, , 1,628 bp in length, has been excessively highlighted to be an essential initiator and facilitator in the process of malignant tumor proliferation and metastasis. As found in many reports, can not only act as a molecular scaffold of PRC2, LSD1 and DNMT1 to epigenetically modify chromosomes in the nucleus but also occur as ceRNA competitively sponging miRNAs in the cytoplasm. Furthermore, may function as a potential biomarker for cancer diagnosis and prognosis. In this review, we summarize the evolvement and mechanisms of in proliferation and metastasis of various human cancers.
多项研究表明，长链非编码RNA（lncRNAs）广泛参与人类癌症的增殖和转移。表观遗传修饰、转录及转录后调控机制均涉及lncRNA介导的肿瘤发生和转移。最近，一种新鉴定出的长度为1628 bp的同源盒（HOX）A11反义lncRNA，在恶性肿瘤增殖和转移过程中被过度强调为重要的启动子和促进因子。正如许多报道中所发现的，它不仅可以作为多梳蛋白2（PRC2）、赖氨酸特异性去甲基化酶1（LSD1）和DNA甲基转移酶1（DNMT1）的分子支架，在细胞核中对染色体进行表观遗传修饰，还可以作为竞争性内源RNA（ceRNA）在细胞质中竞争性结合微小RNA（miRNAs）。此外，它可能作为癌症诊断和预后的潜在生物标志物。在本综述中，我们总结了其在各种人类癌症增殖和转移中的演变及机制。
