Ding Ning, Jiang Jing, Liu Xiaoxiao, Xu Yiyuan, Hu Jiatong, Li Zhigang
Beijing University of Chinese Medicine, Beijing 100029, China.
Evid Based Complement Alternat Med. 2018 Jul 17;2018:7308767. doi: 10.1155/2018/7308767. eCollection 2018.
Acupoints microcirculatory dynamics vary depending on the body's health status. However, the functional changes observed during acupoint sensitization, that is, the disease-induced change from a "silenced" to an "activated" status, remain elusive. In this study, the microcirculatory changes at acupoints during sensitization were characterized. Thirty SD rats were randomly divided into five groups: normal control group (N), sham osteoarthritis group (S), light osteoarthritis group (A), mild osteoarthritis group (B), and heavy osteoarthritis group (C). The obtained results showed that the blood perfusion levels at the acupoints Yanglingquan (GB34), Zusanli (ST36), and Heding (EX-LE2) in groups A, B, and C were higher than those in groups N and S on days 14, 21, and 28 (p < 0.01 or p < 0.05). A significant difference in the blood perfusion was also observed at the acupoint Weizhong (BL40) in groups B and C on days 21 and 28 (p < 0.01). In addition, remarkable differences in the level of blood perfusion at the GB34, ST36, and EX-LE2 acupoints were observed on day 28 (p < 0.01 or p < 0.05) among groups A, B, and C. No marked differences in blood perfusion levels were observed at the nonacupoint site among all groups. In conclusion, acupoint sensitization is associated with an increase in the level of local blood perfusion at specific acupoints, and this increase is positively correlated with the severity of the disease. The functional changes in microcirculation at acupoints during sensitization reflect the different physiological and pathological conditions imposed by the disease.
穴位微循环动力学因身体的健康状况而异。然而，在穴位敏化过程中观察到的功能变化，即疾病诱导的从“沉默”状态到“激活”状态的变化，仍然难以捉摸。在本研究中，对穴位敏化过程中的微循环变化进行了表征。将30只SD大鼠随机分为五组：正常对照组（N）、假骨关节炎组（S）、轻度骨关节炎组（A）、中度骨关节炎组（B）和重度骨关节炎组（C）。所得结果表明，在第14、21和28天，A、B和C组中阳陵泉（GB34）、足三里（ST36）和鹤顶（EX-LE2）穴位的血液灌注水平高于N组和S组（p<0.01或p<0.05）。在第21和28天，B组和C组委中（BL40）穴位的血液灌注也存在显著差异（p<0.01）。此外，在第28天，A、B和C组之间GB34、ST36和EX-LE2穴位的血液灌注水平存在显著差异（p<0.01或p<0.05）。所有组的非穴位部位血液灌注水平均未观察到明显差异。总之，穴位敏化与特定穴位局部血液灌注水平的增加有关，并且这种增加与疾病的严重程度呈正相关。穴位敏化过程中微循环的功能变化反映了疾病所施加的不同生理和病理状况。
