Sayyah Mehdi, Saki-Malehi Amal, Javanmardi Fatemeh, Forouzan Arash, Shirbandi Kiarash, Rahim Fakher
Education Development Center (EDC), Psychiatrist, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Biostatistics and Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Islamic Republic of Iran.
Neurol Neurochir Pol. 2018 Sep-Oct;52(5):562-569. doi: 10.1016/j.pjnns.2018.07.004. Epub 2018 Aug 3.
We conducted this review to systematically assess the association and risk of the migraine in the patient with asthma and vice versa.
We systematically searched publishes articles indexed in PubMed, Scopus, Cochrane library, PsycINFO, CINAHL, ISI Web of Science, Science Direct from inception, and Embase databases until June 2017. The quality assessment of the involved studies was done using the Newcastle-Ottawa Scale (NOS).
Eight studies with 389,573 participants were reviewed and selected for data extraction. Among the selected studies, 5 were reported the association between migraine with asthma risk, and the rest three studies reported the risk of asthma in patient with migraine compared to non-moraine individuals. Odds ratio (OR) of migraine for patient with asthma as compared with non-asthmatic individuals was 1.62 (95% CI 1.43-1.82). Data pooling using a random-effect model showed that migraine was associated with a significant increased risk of asthma (relative risk (RR): 1.56; 95% CI: 1.51-1.60; p < .00001). Besides, sub-group and sensitivity analyses supported the positive association between asthma and migraine, and risk of asthma in migraine patients.
Now it is unknown if control of the asthma will impact the severity of migraines or vice versa, but it is necessary to perform more research to further explain the mechanisms through which asthma increases the frequency of migraine or vice versa. If two conditions linked, once an individual undergo better control of asthma symptoms, might the excruciating migraine ease, too.
我们进行本综述以系统评估哮喘患者患偏头痛的相关性及风险，反之亦然。
我们系统检索了自起始以来在PubMed、Scopus、Cochrane图书馆、PsycINFO、CINAHL、ISI科学网、Science Direct以及Embase数据库中索引的已发表文章，直至2017年6月。使用纽卡斯尔-渥太华量表（NOS）对纳入研究进行质量评估。
对8项研究（共389,573名参与者）进行了综述并选择用于数据提取。在所选研究中，5项报告了偏头痛与哮喘风险之间的关联，其余3项研究报告了偏头痛患者与非偏头痛个体相比患哮喘的风险。哮喘患者患偏头痛的比值比（OR）与非哮喘个体相比为1.62（95%CI 1.43 - 1.82）。使用随机效应模型进行数据合并显示，偏头痛与哮喘风险显著增加相关（相对风险（RR）：1.56；95%CI：1.51 - 1.60；p <.00001）。此外，亚组分析和敏感性分析支持哮喘与偏头痛之间的正相关以及偏头痛患者患哮喘的风险。
目前尚不清楚控制哮喘是否会影响偏头痛的严重程度，反之亦然，但有必要进行更多研究以进一步解释哮喘增加偏头痛发作频率或反之亦然的机制。如果这两种情况相关联，一旦个体对哮喘症状进行更好的控制，令人痛苦的偏头痛是否也会缓解。
