Wohlrab Johannes, Gebert Alexandra, Neubert Reinhard H H
Curr Probl Dermatol. 2018;54:64-70. doi: 10.1159/000489519. Epub 2018 Aug 21.
The pH value is identified as an essential determinant for the lipid synthesis in the stratum corneum (SC). The activity of the enzymes that catalyse the transformation of lipid precursors into ceramides, free fatty acids or cholesterol highly depends on pH value. Additionally, there are substantial indications for pH conditions to have a direct effect on the molecular structure of the membranes and their properties. Knowledge about the sigmoidal pH gradient within the corneal layer also provides understanding of the pathological processes in a dysfunctional barrier. Shifting the pH environment from acidic into alkaline does not only inhibit the regenerating metabolic pathways but also activates enzymes that accelerate desquamation of the SC.
pH值被认为是角质层（SC）脂质合成的一个重要决定因素。催化脂质前体转化为神经酰胺、游离脂肪酸或胆固醇的酶的活性高度依赖于pH值。此外，有大量迹象表明pH条件对膜的分子结构及其性质有直接影响。了解角膜层内的S形pH梯度也有助于理解功能失调屏障中的病理过程。将pH环境从酸性转变为碱性不仅会抑制再生代谢途径，还会激活加速角质层脱屑的酶。
